Ruderman Sarah, Gomes Andrew J, Stoyneva Valentina, Rogers Jeremy D, Fought Angela J, Jovanovic Borko D, Backman Vadim
Biomed Opt Express. 2010 Aug 5;1(2):489-499. doi: 10.1364/BOE.1.000489.
Noninvasive optical techniques for tissue characterization, in particular, light scattering properties and blood supply quantification of mucosa, is useful in a wide variety of applications. However, fiber-optic probes that require contact with the tissue surface can present a challenging problem in the variability of in vivo measurements due the nature of interactions, for example affects due to variations in pressure applied to the probe tip. We present an in vivo evaluation of pressure, angle, and temporal effects on tissue properties for polarization-gated spectroscopy at superficial depths (within 100 to 200 microns of tissue surface) for oral mucosa.
用于组织表征的非侵入性光学技术，特别是用于表征粘膜的光散射特性和血液供应定量的技术，在各种各样的应用中都很有用。然而，由于相互作用的性质，需要与组织表面接触的光纤探头在体内测量的可变性方面可能会带来一个具有挑战性的问题，例如由于施加在探头尖端的压力变化而产生的影响。我们对口腔粘膜在浅表深度（组织表面100至200微米范围内）进行偏振门控光谱时压力、角度和时间对组织特性的影响进行了体内评估。
