彩色匹配和荧光标记食管体模及其应用。
Color-matched and fluorescence-labeled esophagus phantom and its applications.
机构信息
University of Washington, Department of Bioengineering, 204 Fluke Hall, 4000 Mason Road, Seattle, WA 98195, USA.
出版信息
J Biomed Opt. 2013 Feb;18(2):26020. doi: 10.1117/1.JBO.18.2.026020.
Abstract
We developed a stable, reproducible three-dimensional optical phantom for the evaluation of a wide-field endoscopic molecular imaging system. This phantom mimicked a human esophagus structure with flexibility to demonstrate body movements. At the same time, realistic visual appearance and diffuse spectral reflectance properties of the tissue were simulated by a color matching methodology. A photostable dye-in-polymer technology was applied to represent biomarker probed "hot-spot" locations. Furthermore, fluorescent target quantification of the phantom was demonstrated using a 1.2 mm ultrathin scanning fiber endoscope with concurrent fluorescence-reflectance imaging.
摘要
我们开发了一种稳定、可重复的三维光学体模，用于评估广角内窥镜分子成像系统。该体模模拟了具有灵活性的人体食管结构，以演示身体运动。同时，通过配色方法模拟了组织的真实视觉外观和漫反射光谱反射特性。应用光稳定染料-聚合物技术来表示生物标志物探测的“热点”位置。此外，使用具有荧光反射成像功能的 1.2 毫米超薄扫描纤维内窥镜对体模中的荧光靶标进行定量。
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