State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, PR China.
Org Biomol Chem. 2011 Mar 21;9(6):1723-6. doi: 10.1039/c0ob01045f. Epub 2011 Jan 24.
A novel strategy to systematically tune the pK(a) values of rhodamines is described. This strategy was applied to rationally develop compound 1e with a pK(a) of 6.5, the highest among rhodamine amide derivatives, and it could be employed to detect acidic pH variations in living cells with a turn-on signal.
描述了一种系统调节罗丹明 pk(a) 值的新策略。该策略被应用于合理开发 pk(a) 值为 6.5 的化合物 1e，这是罗丹明酰胺衍生物中最高的，可用于检测活细胞中的酸性 pH 变化，并产生开启信号。
