致癌物暴露部位的骨折在软组织镍致癌过程中的作用。
The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue.
作者信息
Ohmori T, Uraga N, Komi K, Tabei R, Shibata T
机构信息
Second Department of Pathology, Ehime University School of Medicine.
出版信息
Jpn J Cancer Res. 1990 Dec;81(12):1247-52. doi: 10.1111/j.1349-7006.1990.tb02686.x.
Abstract
The influence upon nickel subsulfide (alpha-Ni3S2; Ni-SS)-induced carcinogenesis in the soft tissue of bone fracture at the site of Ni-SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction time and survival time, and a significantly higher metastatic rate. The present study may suggest a model for the metastasis of human soft tissue tumors.
摘要
使用雌性Fischer大鼠研究了亚硫化镍（α-Ni3S2；Ni-SS）对Ni-SS暴露部位骨折软组织致癌作用的影响。在为期一年的实验中，遭受骨折的组表现出最短的肿瘤诱导时间和生存时间，以及显著更高的转移率。本研究可能提示了人类软组织肿瘤转移的一种模型。
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