Butcher G A, Garland T, Ajdukiewicz A B, Clark I A
Zoology Department, Australian National University, Canberra, A.C.T.
Trans R Soc Trop Med Hyg. 1990 Sep-Oct;84(5):658-61. doi: 10.1016/0035-9203(90)90134-z.
There is now significant evidence that tumor necrosis factor (TNF) is involved in the pathogenesis of malaria. We have tested sera from patients presenting with a febrile illness admitted to hospital in Honiara, Solomon Islands, for the presence of TNF, interferon-gamma, and interleukin-1 (IL-1). This study differs from previous reports as the subjects were mainly adults from a semi-immune population living in an endemic area. The results from 2 different commercially-available assays for TNF were compared, and one was found to be superior to the other. Serum TNF concentrations correlated with malarial parasite density and the patients' temperatures, but not with interferon or IL-1. The results are discussed in the context of the immunopathology of this disease.
目前有大量证据表明肿瘤坏死因子（TNF）参与疟疾的发病机制。我们检测了来自所罗门群岛霍尼亚拉住院的发热性疾病患者的血清，以检测其中是否存在TNF、γ干扰素和白细胞介素-1（IL-1）。这项研究与以往报告不同，因为研究对象主要是来自生活在流行地区的半免疫人群的成年人。比较了两种不同的市售TNF检测方法的结果，发现其中一种优于另一种。血清TNF浓度与疟原虫密度和患者体温相关，但与干扰素或IL-1无关。本文在该疾病免疫病理学的背景下对结果进行了讨论。
