Department of Radiation Oncology, London Regional Cancer Program, University of Western Ontario, 790 Commissioners Road East, London, ON, Canada.
Radiother Oncol. 2011 Mar;98(3):352-6. doi: 10.1016/j.radonc.2010.12.014. Epub 2011 Jan 22.
To describe the use of radioactive gold grain implantation for squamous cell carcinoma of the lip.
Retrospective review of 51 patients treated with permanent gold ((198)Au) grain implant brachytherapy. The seed arrangement delivered a dose of 5500 cGy at 0.5 cm from a single plane. Primary endpoints were local recurrence and cosmetic outcome.
Median follow-up was 27 months. Median age was 69 years. The majority (90%) were T1 lesions. None of the patients had evidence of regional lymph node or distant metastasis. Twelve patients had recurrent disease with prior surgery and five patients had previous head and neck radiation. Local control was achieved in 49 patients. Good cosmesis was achieved in 48 patients. Two-year actuarial estimates for local failure-free survival, disease-free survival and overall survival were 97.9%, 94.1% and 87.9%, respectively; no deaths were attributable to lip cancer.
Gold grain interstitial low-dose rate brachytherapy provides excellent local control and cosmesis in patients with squamous cell carcinoma of the lip. This technique provides an excellent option for patients that are elder or live remotely. It is particularly useful for lesions that are small, in previously radiated areas, or treated with prior surgery.
描述放射性金（198Au）粒种植近距离放疗在唇鳞癌中的应用。
回顾性分析 51 例接受永久性金粒种植近距离放疗的患者。种子的排列在单一平面上从 0.5cm 处给予 5500cGy 的剂量。主要终点是局部复发和美容结果。
中位随访时间为 27 个月。中位年龄为 69 岁。大多数（90%）为 T1 病变。无局部淋巴结或远处转移的证据。12 例患者在术前有复发病例，5 例患者有头颈部放疗史。49 例患者达到局部控制。48 例患者美容效果良好。2 年局部无失败生存率、无病生存率和总生存率的估计分别为 97.9%、94.1%和 87.9%；无死亡归因于唇癌。
金粒间质低剂量率近距离放疗为唇鳞癌患者提供了极好的局部控制和美容效果。该技术为老年或居住在偏远地区的患者提供了一个极好的选择。它特别适用于小病灶、曾接受过放射治疗或已接受过手术治疗的病灶。
