与故意过量服用马普替林和奋乃静相关的心脏毒性：一例报告。
Cardiotoxicity associated with an intentional overdose of maprotiline and perphenazine: a case report.
作者信息
Jolly D T, Stiell I G
出版信息
Can Fam Physician. 1987 Nov;33:2627-32.
Abstract
Cardiotoxicity is a life-threatening complication of an intentional overdose of cyclic antidepressant and phenothiazine drugs. This case report illustrates the severe conduction abnormalities that can accompany a massive ingestion of maprotiline and perphenazine. The patient's condition was further complicated by the unexpected finding of hypothermia.
摘要
心脏毒性是故意过量服用环类抗抑郁药和吩噻嗪类药物所导致的一种危及生命的并发症。本病例报告阐述了大量摄入马普替林和奋乃静时可能伴随出现的严重传导异常。患者的病情因意外发现体温过低而进一步复杂化。
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Cardiotoxicity associated with an intentional overdose of maprotiline and perphenazine: a case report.与故意过量服用马普替林和奋乃静相关的心脏毒性：一例报告。
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本文引用的文献
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Cardiovascular side effects of phenothiazines and tricyclic antidepressants. A review with precautionary measures.吩噻嗪类和三环类抗抑郁药的心血管副作用。一项附预防措施的综述。
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Toxicity of tricyclic antidepressants--kinetics, mechanism, intervention: a review.三环类抗抑郁药的毒性——动力学、机制、干预：综述
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Seizures and delirium associated with overdosage of maprotiline hydrochloride.盐酸马普替林过量导致的癫痫发作和谵妄
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Q-T prolongation and torsades de pointes ventricular tachycardia produced by the tetracyclic antidepressant agent maprotiline.四环类抗抑郁药麦普替林引起的Q-T间期延长和尖端扭转型室性心动过速。
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