Roy Sp, Niranjan Cm, Jyothi Tm, Shankrayya Mm, Vishawanath Km, Prabhu K, Gouda Va, Setty Rs
Department of Pharmacology, S. C. S. College of Pharmacy, Harapanahalli - 583 131, Karnataka, India.
J Young Pharm. 2010 Oct;2(4):369-73. doi: 10.4103/0975-1483.71629.
The antiulcer and in vitro anti-inflammatory activities of the aerial parts of Enicostemma littorale against aspirin, ethanol, and pyloric ligation-induced ulcers in rats and bovine serum albumin denaturation were studied. The extract (200 mg/kg and 400 mg/kg po) was administered to the overnight fasted rats, one hour prior to aspirin / alcohol / pyloric ligation challenge. The ulcer index, tissue GSH levels, and lipid peroxidation levels were estimated in all the models of ulcers and the volume of gastric secretion, acidity, and pH, were estimated in the pyloric ligation model of ulcers. Pretreatment with the extract showed a dose-dependent decrease in the ulcer index (Against Aspirin, ethanol challenge, and pyloric ligation. The prior administration of the extract also reduced the total acidity, free acidity, and volume of gastric secretion, and elevated the gastric pH. In addition, it was also observed that the extract inhibited the serum albumin denaturation in a dose-dependent manner. It may be concluded that the methanolic extract possesses antiulcer activity, and the anti-inflammatory activity of the extract may be attributed to the antioxidant potential, as reported earlier.
研究了海滨千屈菜地上部分对大鼠阿司匹林、乙醇和幽门结扎诱导的溃疡的抗溃疡和体外抗炎活性以及对牛血清白蛋白变性的影响。提取物（200mg/kg和400mg/kg，口服）在阿司匹林/酒精/幽门结扎攻击前1小时给予过夜禁食的大鼠。在所有溃疡模型中评估溃疡指数、组织谷胱甘肽水平和脂质过氧化水平，并在幽门结扎溃疡模型中评估胃分泌量、酸度和pH值。提取物预处理使溃疡指数呈剂量依赖性降低（针对阿司匹林、乙醇攻击和幽门结扎）。提取物预先给药还降低了总酸度、游离酸度和胃分泌量，并提高了胃pH值。此外，还观察到提取物以剂量依赖性方式抑制血清白蛋白变性。可以得出结论，甲醇提取物具有抗溃疡活性，并且如先前报道的那样，提取物的抗炎活性可能归因于其抗氧化潜力。
