海滨千日红的降血脂和抗氧化作用。
Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume.
作者信息
Thirumalai T, Viviyan Therasa S, Elumalai E K, David E
机构信息
Post Graduate and Research Department of Zoology, Voorhees College, Physiology Wing, Vellore-632 001, Tamilnadu, India.
出版信息
Asian Pac J Trop Biomed. 2011 Oct;1(5):381-5. doi: 10.1016/S2221-1691(11)60084-1.
OBJECTIVE
To investigate the hypolipidaemic and antioxidant effects of aqueous leaf extract of Enicostemma littorale (E. littorale) Blume (Ens) against ethanol induced hepatic injury in albino rats.
METHODS
Male albino rats of six numbers in each group were undertaken for study. Hypolipidaemic and antioxidant effect of E. littorale Blume (Ens) aqueous leaf extract at a dosage of 250 mg/kg bw was evaluated.
RESULTS
Levels of serum and tissue cholesterol, triglycerides and free fatty acids were elevated and levels of tissue thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxide were increased in ethanol treated rats. The activity levels of liver antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione-s-transferase (GST) were decreased. After adiminstration of extract of E. littorale Blume, levels of cholesterol, triglycerides and free fatty acids were decreased in serum and liver tissue, levels of TBARS and lipid hydroperoxide were decreased, and liver antioxidant enzymes were increased in liver tissue.
CONCLUSIONS
It can be concluded that the aqueous leaf extract of E. littorale Blume (Ens) has potent restorative effect on hyperlipidaemic and oxidative stress.
目的
研究滨海沼津草（Enicostemma littorale，Ens）叶水提取物对乙醇诱导的白化大鼠肝损伤的降血脂和抗氧化作用。
方法
每组6只雄性白化大鼠用于研究。评估了剂量为250 mg/kg体重的滨海沼津草（Ens）叶水提取物的降血脂和抗氧化作用。
结果
乙醇处理的大鼠血清和组织中的胆固醇、甘油三酯和游离脂肪酸水平升高，组织硫代巴比妥酸反应物质（TBARS）和脂质氢过氧化物水平增加。肝脏抗氧化酶如超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPX）和谷胱甘肽 - S - 转移酶（GST）的活性水平降低。给予滨海沼津草提取物后，血清和肝组织中的胆固醇、甘油三酯和游离脂肪酸水平降低，TBARS和脂质氢过氧化物水平降低，肝组织中的肝脏抗氧化酶增加。
结论
可以得出结论，滨海沼津草（Ens）叶水提取物对高脂血症和氧化应激具有强大的恢复作用。
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