没食子酸豆幼嫩无种实荚提取物的胃保护作用：多酚成分的作用。
Gastroprotective effect of Acacia nilotica young seedless pod extract: role of polyphenolic constituents.
机构信息
Department of Pharmaceutical Sciences, NIMS University, Jaipur, India.
出版信息
Asian Pac J Trop Med. 2012 Jul;5(7):523-8. doi: 10.1016/S1995-7645(12)60092-3.
OBJECTIVE
To systematically evaluate antiulcer potential of Acacia nilotica in different ulcer models in rats.
METHODS
Different extracts [ethanolic, 50% hydroethanolic (50:50), 70% hydroethanolic (70:30) and aqueous] of young seedless pods were examined in pylorus ligation induced gastric ulcers in rats. Various parameters like, volume of gastric acid secretion, pH, free acidity, total acidity, ulcer index, mucin content and antioxidant studies were determined and were compared between extract treated, standard and vehicle control following ulcer induction. The most active extract was also evaluated in swimming stress induced and NSAID induced gastric ulceration.
RESULTS
Among different extracts of young seedless pods only hydroethanolic extracts showed significant antiulcer activity in pyloric ligation induced ulceration. Even more the 70% hydroethanolic extract showed better protection as compared to 50% hydroethanolic extract. Further 70 % hydroethanolic extract also showed significant mucoprotection in swimming stress induced and nonsteroidal antiinflammatory drugs induced gastric ulceration.
CONCLUSION
The results of present study concluded that the hydroethanolic extract of young seedless pods of Acacia nilotica has antiulcer activity in pylorus ligation, swimming stress and NSAID induced rat ulcer models. The extract containing more amount of phenolic components show high antiulcer activity, indicating the phenolic component of the extract to be responsible for the activity of the extracts.
目的
系统评价金合欢在不同溃疡模型大鼠中的抗溃疡潜力。
方法
考察了未成熟豆荚的不同提取物（乙醇、50% 水醇（50:50）、70% 水醇（70:30）和水提物）对大鼠幽门结扎型胃溃疡的作用。在诱导溃疡后，测定了各种参数，如胃酸分泌量、pH 值、游离酸度、总酸度、溃疡指数、粘蛋白含量和抗氧化研究，并将提取物处理组、标准组和载体对照组进行了比较。还评价了最活跃的提取物在游泳应激和 NSAID 诱导的胃溃疡中的作用。
结果
在未成熟豆荚的不同提取物中，只有水醇提取物在幽门结扎诱导的溃疡中表现出显著的抗溃疡活性。更重要的是，70%水醇提取物比 50%水醇提取物具有更好的保护作用。此外，70%水醇提取物在游泳应激和非甾体抗炎药诱导的胃溃疡中也表现出显著的粘蛋白保护作用。
结论
本研究的结果表明，金合欢未成熟豆荚的水醇提取物在幽门结扎、游泳应激和 NSAID 诱导的大鼠溃疡模型中具有抗溃疡活性。含有更多酚类成分的提取物表现出较高的抗溃疡活性，表明提取物中的酚类成分是提取物活性的原因。
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