苏丹结直肠癌患者酸性粘蛋白定性变化的评估
Assessment of qualitative changes of Acid mucins among sudanese colorectal carcinoma patients.
作者信息
Zakout Yosef Mohamed-Azzam, Ezeldeen Yousra Altegani
机构信息
Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, P.O. Box 11081, Khartoum, 11111, Sudan.
出版信息
J Gastrointest Cancer. 2012 Jun;43(2):205-8. doi: 10.1007/s12029-010-9246-9.
PURPOSE
This study aimed to assess the qualitative changes in the amount of acid mucin in colorectal carcinoma (CRC) compared to normal colon.
METHODS
A total number of 100 samples were examined, 50 were colorectal cancer samples (cases) and 50 were normal (controls), all were stained with Alcian blue method.
RESULTS
Acid mucin increased, in different levels, in 30 (60%) of the cases compared to only six (12%) of controls (P < 0.0001). However, complete absence of acid mucin was detected among 10 (20%) of cases compared to none among controls.
CONCLUSIONS
CRC is associated with secretion of increased amounts of acid mucin in most cases, and that should be considered as a valuable histological finding.
目的
本研究旨在评估与正常结肠相比，结直肠癌（CRC）中酸性黏蛋白含量的定性变化。
方法
共检查了100个样本，其中50个是结直肠癌样本（病例），50个是正常样本（对照），所有样本均采用阿尔辛蓝染色法。
结果
与仅6例（12%）对照相比，30例（60%）病例中的酸性黏蛋白有不同程度增加（P < 0.0001）。然而，10例（20%）病例中检测到完全没有酸性黏蛋白，而对照中未发现。
结论
在大多数情况下，结直肠癌与酸性黏蛋白分泌增加有关，这应被视为一项有价值的组织学发现。
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