Department of Infection Prevention and Control, New York Presbyterian Hospital, NY 10032, USA.
Am J Infect Control. 2011 Apr;39(3):247-9. doi: 10.1016/j.ajic.2010.06.027. Epub 2011 Jan 26.
An immunocompetent health care worker with no known history of varicella-zoster virus (VZV) disease was exposed to a patient with herpes zoster and was immunized 2 days later. Twenty-seven days after receiving the varicella vaccine, while hospitalized, she developed a disseminated rash. This exposure and subsequent development of symptoms posed infection control challenges. A polymerase chain reaction analysis of her vesicular fluid was positive for vaccine-type VZV, and a blood specimen collected before vaccination demonstrated a positive VZV titer by the fluorescent antibody to membrane antigen test. To the best of our knowledge, there have been no previous reports of an immunocompetent seropositive person developing vaccine-type VZV after receiving the vaccine.
一名免疫功能正常的医护人员，无水痘-带状疱疹病毒（VZV）疾病史，接触了一名带状疱疹患者，2 天后接种了疫苗。在接种水痘疫苗后 27 天，她住院时出现了全身性皮疹。这种接触和随后出现的症状给感染控制带来了挑战。她水疱液的聚合酶链反应分析显示为疫苗型 VZV 阳性，而在接种疫苗前采集的血液样本通过膜抗原荧光抗体试验显示 VZV 滴度阳性。据我们所知，此前尚无免疫功能正常的血清阳性者在接种疫苗后出现疫苗型 VZV 的报告。
