Department of Physiology and Florey Neurosciences Institutes, University of Melbourne, Vic., 3010, Australia.
Curr Opin Pharmacol. 2011 Apr;11(2):117-23. doi: 10.1016/j.coph.2010.12.003. Epub 2011 Jan 25.
Whilst crucial for behavioural and homeostatic responses to environmental challenges, chronic elevation of sympathetic nervous system activity to specific vascular beds is associated with hypertension. Indeed such elevated activity may drive the increase in blood pressure seen in some people and in some experimental models of hypertension. This review discusses the neural circuitry involved in generating and modulating sympathetic efferent nerve activity, focusing on the premotor neurons of the rostral ventrolateral medulla. Neurons in the rostral ventrolateral medulla show altered responses to angiotensin II in experimental models of hypertension, suggesting that this might be an important node for interaction between these two systems that are crucial for regulation of blood pressure.
虽然交感神经系统对环境挑战的行为和稳态反应至关重要，但对特定血管床的交感神经系统活性的慢性升高与高血压有关。事实上，这种升高的活性可能会导致一些人和一些高血压实验模型中血压升高。这篇综述讨论了产生和调节交感传出神经活动的神经回路，重点是延髓头端腹外侧区的运动前神经元。高血压实验模型中，延髓头端腹外侧区的神经元对血管紧张素 II 的反应发生改变，这表明这可能是这两个系统之间相互作用的一个重要节点，这对于血压调节至关重要。
