Parente Leila Maria Leal, Andrade Maria Auxiliadora, Brito Luiz Augusto Batista, Moura Veridiana Maria Brianezi Dignani de, Miguel Marina Pacheco, Lino-Júnior Ruy de Souza, Tresvenzol Leonice Faustino Manrique, Paula José Realino de, Paulo Neusa Margarida
Department of Pathology, UFG, Goias, Brazil.
Acta Cir Bras. 2011 Feb;26(1):19-24. doi: 10.1590/s0102-86502011000100005.
In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant.
Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats.
The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors.
The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.
鉴于药用特性，尤其是愈合活性，归因于金盏花（菊科），本研究对其乙醇提取物、二氯甲烷和己烷馏分的血管生成活性进行了评估。
分别通过诱导皮肤伤口和鸡胚绒毛尿囊膜，使用36只大鼠和90枚受精鸡蛋的模型来评估该植物提取物和馏分的愈合和血管生成活性。还通过该研究测试血管增殖的效果，以验证大鼠皮肤伤口中血管内皮生长因子（VEGF）的表达强度。
提取物和馏分在两种实验模型中均表现出血管生成活性。证实这种作用与VEGF的表达没有直接关系，可能与其他促血管生成因子有关。
金盏花的愈合活性除其他因素外，与其对血管生成的积极作用有关，其特征是诱导新血管形成。
