Alexandrescu Doru T, Riordan Neil H, Ichim Thomas E, Kauffman C Lisa, Kabigting Filamer, Dutton Constance T, Dasanu Constantin A
Georgetown Dermatology, Washington, DC, USA.
Dermatol Online J. 2011 Jan 15;17(1):10.
A various array of cutaneous granulomatous disorders have been found to be associated with internal malignancy. Among them, sarcoidosis, granuloma anulare (GA), psoriasis, pyoderma gangrenosum (PG), or other neutrophilic dermatoses such as the Sweet syndrome and subcorneal pustular dermatosis may precede the development of a neoplastic process by months or years. Pathogenic links of inflammation with cancer are discussed, including inflammation, intrinsic immune dysfunction, cytokines and interleukins, angiogenetic factors, and epigenetic changes.
一系列各种各样的皮肤肉芽肿性疾病已被发现与体内恶性肿瘤有关。其中，结节病、环状肉芽肿（GA）、银屑病、坏疽性脓皮病（PG）或其他嗜中性皮病，如Sweet综合征和角层下脓疱性皮病，可能在肿瘤形成过程发生前数月或数年出现。本文讨论了炎症与癌症的致病联系，包括炎症、内在免疫功能障碍、细胞因子和白细胞介素、血管生成因子以及表观遗传变化。
