乳酸奈瑟菌和多糖奈瑟菌作为通过基因转化产生脑膜炎球菌β-内酰胺耐药性的可能来源。
Neisseria lactamica and Neisseria polysaccharea as possible sources of meningococcal beta-lactam resistance by genetic transformation.
作者信息
Saez-Nieto J A, Lujan R, Martinez-Suarez J V, Berron S, Vazquez J A, Viñas M, Campos J
机构信息
Laboratorio de Referencia de Meningococos, Centro Nacional de Microbiologia, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 1990 Nov;34(11):2269-72. doi: 10.1128/AAC.34.11.2269.
Abstract
We studied the susceptibilities of relatively penicillin G-resistant and -susceptible strains of Neisseria meningitidis, as well as Neisseria lactamica and Neisseria polysaccharea, to penicillin, ampicillin, and several cephalosporins. The MICs of penicillin, ampicillin, cephalothin, and cefuroxime for moderately resistant meningococci have increased two- to sixfold in relation to MICs for susceptible strains. For these strains of meningococci, N. lactamica, and N. polysaccharea, penicillin, ampicillin, cephalothin, and cefuroxime MICs for 50 and 90% of strains were similar. By genetic transformation of a penicillin-susceptible strain of N. meningitidis to low-level penicillin resistance with DNA from penicillin-resistant strains of N. meningitidis, N. lactamica, N. polysaccharea, and N. gonorrhoeae, isogenic strains with the same pattern of resistance to beta-lactams were obtained, suggesting that these commensal Neisseria spp. could be the source of meningococcal resistance genes.
摘要
我们研究了相对耐青霉素G和对青霉素G敏感的脑膜炎奈瑟菌菌株，以及乳酸奈瑟菌和多糖奈瑟菌对青霉素、氨苄西林和几种头孢菌素的敏感性。中度耐药脑膜炎球菌对青霉素、氨苄西林、头孢噻吩和头孢呋辛的最低抑菌浓度（MIC）相较于敏感菌株增加了2至6倍。对于这些脑膜炎球菌菌株、乳酸奈瑟菌和多糖奈瑟菌，50%和90%菌株的青霉素MIC、氨苄西林MIC、头孢噻吩MIC和头孢呋辛MIC相似。通过用来自耐青霉素的脑膜炎奈瑟菌、乳酸奈瑟菌、多糖奈瑟菌和淋病奈瑟菌菌株的DNA将一株对青霉素敏感的脑膜炎奈瑟菌转化为低水平青霉素耐药，获得了对β-内酰胺具有相同耐药模式的同基因菌株，这表明这些共生奈瑟菌属可能是脑膜炎球菌耐药基因的来源。
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