16种抗菌剂对青霉素敏感的脑膜炎球菌和对青霉素敏感性降低的脑膜炎球菌的体外比较活性
Comparative activity in vitro of 16 antimicrobial agents against penicillin-susceptible meningococci and meningococci with diminished susceptibility to penicillin.
作者信息
Pérez Trallero E, Garcia Arenzana J M, Ayestaran I, Muñoz Baroja I
机构信息
Servicio de Microbiologia, Hospital NS Aranzazu, Unidad Docente San Sebastian, Spain.
出版信息
Antimicrob Agents Chemother. 1989 Sep;33(9):1622-3. doi: 10.1128/AAC.33.9.1622.
Abstract
Broad-spectrum cephalosporins were very active against strains of Neisseria meningitidis with both penicillin susceptibility and diminished penicillin susceptibility. Ceftriaxone was the most active antibiotic. Increases in MIC for 90% of meningococci with diminished susceptibility to penicillin of greater than or equal to 16-fold were observed for amdinocillin, cefuroxime, aztreonam, and imipenem; 2-fold increases were observed for ceftazidime, mezlocillin, and piperacillin. No differences were observed for non-beta-lactam antibiotics.
摘要
广谱头孢菌素对青霉素敏感和青霉素敏感性降低的脑膜炎奈瑟菌菌株均具有很高的活性。头孢曲松是活性最强的抗生素。对于对青霉素敏感性降低大于或等于16倍的90%的脑膜炎球菌，氨曲南、头孢呋辛、氨曲南和亚胺培南的最低抑菌浓度（MIC）有所增加；头孢他啶、美洛西林和哌拉西林的MIC增加了2倍。非β-内酰胺类抗生素未观察到差异。
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