经皮消融的原理与进展
Principles of and advances in percutaneous ablation.
作者信息
Ahmed Muneeb, Brace Christopher L, Lee Fred T, Goldberg S Nahum
机构信息
Laboratory for Minimally Invasive Tumor Therapy, Section of Interventional Radiology, and Section of Abdominal Imaging, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Rd, Boston, MA 02215, USA.
出版信息
Radiology. 2011 Feb;258(2):351-69. doi: 10.1148/radiol.10081634.
Abstract
Image-guided tumor ablation with both thermal and nonthermal sources has received substantial attention for the treatment of many focal malignancies. Increasing interest has been accompanied by continual advances in energy delivery, application technique, and therapeutic combinations with the intent to improve the efficacy and/or specificity of ablative therapies. This review outlines clinical percutaneous tumor ablation technology, detailing the science, devices, techniques, technical obstacles, current trends, and future goals in percutaneous tumor ablation. Methods such as chemical ablation, cryoablation, high-temperature ablation (radiofrequency, microwave, laser, and ultrasound), and irreversible electroporation will be discussed. Advances in technique will also be covered, including combination therapies, tissue property modulation, and the role of computer modeling for treatment optimization.
摘要
利用热和非热能源进行图像引导的肿瘤消融在许多局灶性恶性肿瘤的治疗中受到了广泛关注。随着对其兴趣的不断增加，能量传递、应用技术以及治疗组合方面也在不断取得进展，目的是提高消融治疗的疗效和/或特异性。本综述概述了临床经皮肿瘤消融技术，详细介绍了经皮肿瘤消融的科学原理、设备、技术、技术障碍、当前趋势以及未来目标。将讨论化学消融、冷冻消融、高温消融（射频、微波、激光和超声）以及不可逆电穿孔等方法。还将涵盖技术进展，包括联合治疗、组织特性调节以及计算机建模在治疗优化中的作用。
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