• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从人垂体中分离、鉴定及合成促肾上腺皮质激素抑制肽。

Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.

作者信息

Li C H, Chung D, Yamashiro D, Lee C Y

出版信息

Proc Natl Acad Sci U S A. 1978 Sep;75(9):4306-9. doi: 10.1073/pnas.75.9.4306.

DOI:10.1073/pnas.75.9.4306
PMID:212744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336102/
Abstract

A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity of the peptide is estimated to be 30% of the potency of ACTH. It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.

摘要

一种促肾上腺皮质激素抑制肽（CIP）已从人垂体提取物中分离出来。它由32个氨基酸组成，推测序列与促肾上腺皮质激素（ACTH）的7 - 38位残基相同。该肽已通过固相法合成。该肽的促黑素活性估计为ACTH效力的30%。它没有皮质类固醇生成活性，但能够抑制分离的大鼠肾上腺细胞中ACTH刺激的皮质酮生成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06df/336102/43dcb6c9cc11/pnas00668-0245-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06df/336102/43dcb6c9cc11/pnas00668-0245-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06df/336102/43dcb6c9cc11/pnas00668-0245-a.jpg

相似文献

1
Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.从人垂体中分离、鉴定及合成促肾上腺皮质激素抑制肽。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4306-9. doi: 10.1073/pnas.75.9.4306.
2
Isolation and structure of corticostatin peptides from rabbit fetal and adult lung.从兔胎儿和成年肺中分离并鉴定促肾上腺皮质素抑制因子肽的结构。
Proc Natl Acad Sci U S A. 1988 Jan;85(2):592-6. doi: 10.1073/pnas.85.2.592.
3
Occurrence of a new corticotropin-like intermediate lobe peptide in salmon pituitary glands.鲑鱼垂体中一种新的促肾上腺皮质激素样中间叶肽的出现。
Arch Biochem Biophys. 1982 Feb;213(2):680-8. doi: 10.1016/0003-9861(82)90598-7.
4
Purification and partial chemical characterization of human pituitary lipolytic hormone.
Can J Biochem. 1976 Sep;54(9):778-82. doi: 10.1139/o76-111.
5
Corticotropin-releasing hormone (CRH) directly stimulates corticosterone secretion by the rat adrenal gland.促肾上腺皮质激素释放激素（CRH）直接刺激大鼠肾上腺分泌皮质酮。
Endocrinology. 1991 Feb;128(2):1198-200. doi: 10.1210/endo-128-2-1198.
6
Isolation and mode of action of rabbit corticostatic (antiadrenocorticotropin) peptides.
Endocrinology. 1992 Mar;130(3):1413-23. doi: 10.1210/endo.130.3.1311240.
7
The isolation and characterization of corticotropin from the pituitary gland of the ostrich Struthio camelus.从鸵鸟（Struthio camelus）垂体中分离并鉴定促肾上腺皮质激素。
Biochem J. 1977 Sep 1;165(3):519-23. doi: 10.1042/bj1650519.
8
Beta-endorphin-related peptides in the human pituitary. Isolation and characterization of major immunoreactive peptides, including the formerly unrecognized peptide beta-endorphin 1-18.人垂体中与β-内啡肽相关的肽。主要免疫反应性肽的分离与鉴定，包括之前未被识别的肽β-内啡肽1-18。
Acta Physiol Scand Suppl. 1984;531:1-84.
9
Isolation and characterization of beta-lipotropin and adrenocorticotropin from turkey pituitary glands.从火鸡脑垂体中分离并鉴定β-促脂解素和促肾上腺皮质激素。
Int J Pept Protein Res. 1980 Mar;15(3):261-70. doi: 10.1111/j.1399-3011.1980.tb02576.x.
10
Purification and characterization of a gamma-melanotropin precursor from frozen human pituitary glands.从冷冻人垂体中纯化和鉴定一种γ-促黑素原
Biochem J. 1980 Oct 1;191(1):125-32. doi: 10.1042/bj1910125.

引用本文的文献

1
ACTH Antagonists.促肾上腺皮质激素拮抗剂
Front Endocrinol (Lausanne). 2016 Aug 5;7:101. doi: 10.3389/fendo.2016.00101. eCollection 2016.
2
Phase-dependent resetting of the adrenal clock by ACTH in vitro.体外 ACTH 对肾上腺时钟的时相依赖性重置。
Am J Physiol Regul Integr Comp Physiol. 2014 Mar 15;306(6):R387-93. doi: 10.1152/ajpregu.00519.2013. Epub 2014 Jan 29.
3
Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats.

本文引用的文献

1
DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.圆盘电泳。II. 方法及其在人血清蛋白中的应用。
Ann N Y Acad Sci. 1964 Dec 28;121:404-27. doi: 10.1111/j.1749-6632.1964.tb14213.x.
2
PARTITION CHROMATOGRAPHY OF OXYTOCIN ON 'SEPHADEX'.催产素在“葡聚糖凝胶”上的分配色谱法
Nature. 1964 Jan 4;201:76-7. doi: 10.1038/201076a0.
3
ADRENOCORTICOTROPIN. XXVII. ON THE PRESENCE OF PIG-TYPE ADRENOCORTICOTROPIN IN SHEEP PITUITARIES, AND A SIMPLE METHOD FOR THE ISOLATION OF ALPHA-S-ADRENOCORTICOTROPIN.促肾上腺皮质激素。XXVII. 绵羊垂体中猪型促肾上腺皮质激素的存在，以及一种分离α-S-促肾上腺皮质激素的简单方法。
有证据表明，大鼠下丘脑外垂体促肾上腺皮质激素释放激素（CRH）/促肾上腺皮质激素（ACTH）系统可控制肾上腺的生长和分泌。
Cell Tissue Res. 1993 Jun;272(3):439-45. doi: 10.1007/BF00318550.
4
Beta subunits of human choriogonadotropin and ovine lutropin are biologically active.人绒毛膜促性腺激素的β亚基和绵羊促黄体生成素具有生物活性。
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2500-3. doi: 10.1073/pnas.79.8.2500.
5
Effects of beta-lipotropin and beta-lipotropin-derived peptides on aldosterone production in the rat adrenal gland.β-促脂素及β-促脂素衍生肽对大鼠肾上腺醛固酮分泌的影响。
J Clin Invest. 1981 Sep;68(3):752-9. doi: 10.1172/jci110311.
6
ACTH increases noradrenaline release in the rabbit heart.促肾上腺皮质激素增加兔心脏中去甲肾上腺素的释放。
Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):368-72. doi: 10.1007/BF00172111.
7
Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary.正常人垂体中源自阿片促黑皮质素原的α-酰胺化肽。
Biochem J. 1988 Mar 15;250(3):781-8. doi: 10.1042/bj2500781.
8
Purification to homogeneity of camel pituitary pro-opiocortin, the common precursor of opioid peptides and corticotropin.骆驼垂体阿片促黑皮质素原（阿片肽和促肾上腺皮质激素的共同前体）的纯化至均一性。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1756-9. doi: 10.1073/pnas.76.4.1756.
Biochim Biophys Acta. 1963 Sep 10;74:763-73. doi: 10.1016/0006-3002(63)91428-8.
4
In vitro bioassay for the melanocyte stimulating hormone.促黑素细胞激素的体外生物测定
Endocrinology. 1954 May;54(5):553-60. doi: 10.1210/endo-54-5-553.
5
Recent studies on the problems involved in the preparation, properties and bioassay of adrenocorticotrophic hormone.近期关于促肾上腺皮质激素的制备、性质及生物测定所涉及问题的研究。
Acta Endocrinol (Copenh). 1952 Jul;10(3):255-91. doi: 10.1530/acta.0.0100255.
6
Separation of dansyl-amino acids by polyamide layer chromatography.用聚酰胺薄层层析法分离丹磺酰氨基酸。
Biochim Biophys Acta. 1967 Feb 21;133(2):369-70. doi: 10.1016/0005-2795(67)90078-5.
7
Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride.无水氟化氢在肽合成中的应用。I. 各种保护基在无水氟化氢中的行为。
Bull Chem Soc Jpn. 1967 Sep;40(9):2164-7. doi: 10.1246/bcsj.40.2164.
8
Increased coupling yields in solid phase peptide synthesis with a modified carbodiimide coupling procedure.采用改良的碳二亚胺偶联方法提高固相肽合成中的偶联产率。
Hoppe Seylers Z Physiol Chem. 1972 Dec;353(12):1973-6.
9
Steroidogenesis and cyclic adenosine 3',5'-monophosphate accumulation in rat adrenal cells. Divergent effects of adrenocorticotropin and its o-nitrophenyl sulfenyl derivative.大鼠肾上腺细胞中的类固醇生成及环磷酸腺苷积累。促肾上腺皮质激素及其邻硝基苯硫基衍生物的不同作用。
J Biol Chem. 1973 Apr 10;248(7):2409-17.
10
Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method.促肾上腺皮质激素。44. 用固相法全合成人体激素。
J Am Chem Soc. 1973 Feb 21;95(4):1310-5. doi: 10.1021/ja00785a049.