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骆驼垂体阿片促黑皮质素原（阿片肽和促肾上腺皮质激素的共同前体）的纯化至均一性。

Purification to homogeneity of camel pituitary pro-opiocortin, the common precursor of opioid peptides and corticotropin.

作者信息

Kimura S, Lewis R V, Gerber L D, Brink L, Rubinstein M, Stein S, Udenfriend S

出版信息

Proc Natl Acad Sci U S A. 1979 Apr;76(4):1756-9. doi: 10.1073/pnas.76.4.1756.

DOI:10.1073/pnas.76.4.1756
PMID:221906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383469/
Abstract

Pro-opiocortin was purified from camel pituitaries by procedures including high-performance liquid chromatography. The precursor relationship of the pure protein to the opioid peptides and to corticotropin was confirmed. Partial chemical analysis consisting of amino acid analysis and tryptic peptide mapping was carried out with the aid of sensitive fluorescence detection.

摘要

通过包括高效液相色谱在内的方法从骆驼垂体中纯化出阿片皮质素原。证实了该纯蛋白与阿片肽及促肾上腺皮质激素之间的前体关系。借助灵敏的荧光检测进行了包括氨基酸分析和胰蛋白酶肽图谱分析在内的部分化学分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed1b/383469/e9acc26e667e/pnas00004-0240-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed1b/383469/e9acc26e667e/pnas00004-0240-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed1b/383469/e9acc26e667e/pnas00004-0240-a.jpg

相似文献

1
Purification to homogeneity of camel pituitary pro-opiocortin, the common precursor of opioid peptides and corticotropin.骆驼垂体阿片促黑皮质素原（阿片肽和促肾上腺皮质激素的共同前体）的纯化至均一性。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1756-9. doi: 10.1073/pnas.76.4.1756.
2
Characterization of pro-opiocortin, a precursor to opioid peptides and corticotropin.阿片肽和促肾上腺皮质激素的前体——阿片促皮质素原的特性分析
Proc Natl Acad Sci U S A. 1978 Feb;75(2):669-71. doi: 10.1073/pnas.75.2.669.
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Common precursor to corticotropins and endorphins.促肾上腺皮质激素和内啡肽的共同前体。
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Proc Natl Acad Sci U S A. 1979 Oct;76(10):5085-9. doi: 10.1073/pnas.76.10.5085.
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Purification and characterization of amino-terminal pro-opiocortin peptides from human pituitary glands.
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Biochem Biophys Res Commun. 1979 Jul 27;89(2):360-7. doi: 10.1016/0006-291x(79)90638-7.

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Immunological and chemical identification of intracellular forms of adenovirus type 2 terminal protein.2型腺病毒末端蛋白细胞内形式的免疫学和化学鉴定
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本文引用的文献

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The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
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Amino acid analysis with fluorescamine at the picomole level.皮摩尔水平的荧光胺氨基酸分析。
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An 18,200-dalton adrenal protein that contains four [Met]enkephalin sequences.一种18200道尔顿的肾上腺蛋白，含有四个甲硫氨酸脑啡肽序列。
Proc Natl Acad Sci U S A. 1982 May;79(9):3057-61. doi: 10.1073/pnas.79.9.3057.
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Adrenal opioid proteins of 8600 and 12,600 daltons: intermediates in proenkephalin processing.8600道尔顿和12,600道尔顿的肾上腺阿片样蛋白：脑啡肽原加工过程中的中间体。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):2096-100. doi: 10.1073/pnas.79.6.2096.
6
Enkephalin biosynthetic pathway: proteins of 8000 and 14,000 daltons in bovine adrenal medulla.脑啡肽生物合成途径：牛肾上腺髓质中8000和14000道尔顿的蛋白质。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):5018-20. doi: 10.1073/pnas.77.8.5018.
7
Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers.吸烟产生的尼古丁会使男性慢性吸烟者体内皮质醇、生长激素和催乳素的循环水平升高。
Psychopharmacology (Berl). 1982;78(4):305-8. doi: 10.1007/BF00433730.
8
Intact proenkephalin is the major enkephalin-containing peptide produced in rat adrenal glands after denervation.完整的前脑啡肽是大鼠肾上腺去神经支配后产生的主要含脑啡肽肽。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7985-8. doi: 10.1073/pnas.81.24.7985.
9
Processing of the precursor to corticotropin and beta-lipotropin in humans.人类促肾上腺皮质激素和β-促脂素前体的加工过程。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5211-5. doi: 10.1073/pnas.77.9.5211.
10
Isolation, structure, biological characterization, and synthesis of beta-[Tyr9]melanotropin-(9-18) decapeptide from pig hypothalami.从猪下丘脑分离、结构分析、生物学特性鉴定及合成β-[酪氨酸9]促黑素细胞激素-(9 - 18)十肽
Proc Natl Acad Sci U S A. 1980 Jul;77(7):3947-51. doi: 10.1073/pnas.77.7.3947.
Nat New Biol. 1973 Jul 18;244(133):65-7. doi: 10.1038/newbio244065a0.
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Automatic Monitoring of primary amines in preparative column effluents with fluorescamine.使用荧光胺自动监测制备柱流出物中的伯胺。
Anal Biochem. 1975 Aug;67(2):438-45. doi: 10.1016/0003-2697(75)90316-4.
5
Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.α-内啡肽和γ-内啡肽的分离、一级结构及合成，这两种源于下丘脑 - 垂体且具有吗啡样活性的肽。
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3942-6. doi: 10.1073/pnas.73.11.3942.
6
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.从骆驼脑垂体中分离出具有阿片样活性的三十一肽并解析其结构。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1145-8. doi: 10.1073/pnas.73.4.1145.
7
Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin.从大鼠垂体中分离和鉴定阿片肽：β-内啡肽。
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4969-72. doi: 10.1073/pnas.74.11.4969.
8
Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-beta-lipotropin precursor.构建含有牛促肾上腺皮质激素-β-促脂素前体核苷酸序列的细菌质粒。
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6021-5. doi: 10.1073/pnas.75.12.6021.
9
Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.从人垂体中分离、鉴定及合成促肾上腺皮质激素抑制肽。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4306-9. doi: 10.1073/pnas.75.9.4306.
10
Steps involved in the processing of common precursor forms of adrenocorticotropin and endorphin in cultures of mouse pituitary cells.小鼠垂体细胞培养物中促肾上腺皮质激素和内啡肽常见前体形式的加工过程中涉及的步骤。
Biochemistry. 1978 Aug 22;17(17):3609-18. doi: 10.1021/bi00610a030.