Department of Health Risk Management, China Medical University, Taichung, Taiwan, Republic of China.
Environ Sci Pollut Res Int. 2011 Jul;18(6):877-89. doi: 10.1007/s11356-011-0447-y. Epub 2011 Jan 28.
This study assessed the potential exposure risks for workers in the workplace exposed to airborne titanium dioxide nanoparticles (TiO(2)-NPs) and carbon black nanoparticles (CB-NPs). The risk management control strategies were also developed for the NP engineering workplace.
The method used in this study was based on the integrated multiple-path particle dosimetry model to estimate the cumulative dose of nanoparticles (NPs) in the human lung. The study then analyzed toxicological effects such as pulmonary cytotoxicity and inflammation and evaluated the health risk associated with exposure to NPs in the workplace. Risk control measures such as the use of ventilating systems and N95 respirator protection are also discussed.
This study found that: (1) the cumulative dose of CB-NPs was greater than that of TiO(2)-NPs in human lungs; (2) there is a potential health risk to workers exposed to TiO(2)-NPs and CB-NPs in the absence of control measures in the workplace, with higher health risks associated with CB-NPs than TiO(2)-NPs; and (3) the use of a ventilating system and an N95 respirator offers greater protection in the workplace and significantly reduces the health risks associated with NP exposure.
The present risk management control strategy suggests that the most effective way to reduce airborne NPs is to incorporate the use of a ventilating system combined with N95 respirator protection. This will enable the concentrations of TiO(2)-NPs and CB-NPs to be reduced to acceptable exposure levels.
本研究评估了空气中二氧化钛纳米颗粒(TiO2-NPs)和炭黑纳米颗粒(CB-NPs)暴露于工作场所工人的潜在暴露风险。还为 NP 工程工作场所制定了风险管理控制策略。
本研究中使用的方法基于综合多路径颗粒剂量学模型来估计人肺中纳米颗粒(NPs)的累积剂量。然后,该研究分析了肺细胞毒性和炎症等毒理学效应,并评估了与工作场所中 NPs 暴露相关的健康风险。还讨论了通风系统和 N95 呼吸器防护等风险控制措施。
本研究发现:(1)人肺中 CB-NPs 的累积剂量大于 TiO2-NPs;(2)在工作场所没有控制措施的情况下,暴露于 TiO2-NPs 和 CB-NPs 的工人存在潜在的健康风险,暴露于 CB-NPs 的健康风险高于 TiO2-NPs;(3)在工作场所使用通风系统和 N95 呼吸器提供了更大的保护,显著降低了与 NP 暴露相关的健康风险。
本风险管理控制策略表明,减少空气中 NPs 的最有效方法是结合使用通风系统和 N95 呼吸器防护。这将使 TiO2-NPs 和 CB-NPs 的浓度降低到可接受的暴露水平。