Department of Biochemistry, University of Craiova, A.I. Cuza Str., Nr. 13, Craiova, Romania.
Biol Trace Elem Res. 2011 Dec;143(3):1223-38. doi: 10.1007/s12011-011-8972-6. Epub 2011 Jan 28.
Calcium fructoborate is a boron-based nutritional supplement. Its chemical structure is similar to one of the natural forms of boron such as bis-manitol, bis-sorbitol, bis-fructose, and bis-sucrose borate complexes found in edible plants. In vitro studies revealed that calcium fructoborate is a superoxide ion scavenger and anti-inflammatory agent. It may influence macrophage production of inflammatory mediators, can be beneficial for the suppression of cytokine production, and inhibits progression of endotoxin-associated diseases, as well as the boric acid and other boron sources. The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1β, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-α production. Also, calcium fructoborate has no effects on lipopolysaccharide-induced cyclooxygenase-2 protein express. The studies on animals and humans with a dose range of 1-7 mg calcium fructoborate (0.025-0.175 mg elemental boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible adverse effect on humans.
钙果硼酸酯是一种硼基营养补充剂。其化学结构与存在于食用植物中的天然硼形式之一（如甘露糖醇硼酸酯、山梨糖醇硼酸酯、果聚糖硼酸酯和蔗糖硼酸酯）相似。体外研究表明，钙果硼酸酯是一种超氧阴离子清除剂和抗炎剂。它可能影响巨噬细胞产生炎症介质，有利于抑制细胞因子的产生，并抑制内毒素相关疾病的进展，以及硼酸和其他硼源。钙果硼酸酯发挥其有益抗炎作用的机制尚不完全清楚，但已了解其一些分子生物学的体外活性：抑制细胞内的超氧；抑制细胞培养上清液中白细胞介素-1β、白细胞介素-6 和一氧化氮的释放；并增加肿瘤坏死因子-α的产生。此外，钙果硼酸酯对脂多糖诱导的环加氧酶-2 蛋白表达没有影响。在动物和人体中的研究剂量范围为 1-7mg 钙果硼酸酯（0.025-0.175mg 元素硼）/kg 体重/天，表现出良好的抗炎活性，而且似乎对人体也没有明显的不良影响。
