血根碱对成纤维细胞溶酶体功能活性的影响
[Effect of sanguiritrine on the functional activity of fibroblast lysosomes].
作者信息
Beliaeva T N, Bulychev A G, Lasskaia O E, Semenova E G
出版信息
Vopr Med Khim. 1990 Nov-Dec;36(6):16-8.
PMID:2127488
Abstract
Kinetics of sanguiritrine consumption by L cells of LSM substrain was studied in cell culture. About half of the drug used was absorbed by cells within 20 min. Sanguiritrine inhibited the lysosomal hydrolases (cathepsin D, beta-D-galactosidase and N-acetyl-beta-D-glucosaminidase) activity by 50% at concentration 2.10(-4) M. The drug a concentration 4.10(-4) M inhibited acid lipase by 55% and acid phosphatase by 58%.
摘要
在细胞培养中研究了LSM亚系L细胞对血根碱的摄取动力学。所用药物约一半在20分钟内被细胞吸收。血根碱在浓度为2×10⁻⁴ M时可抑制溶酶体水解酶（组织蛋白酶D、β-D-半乳糖苷酶和N-乙酰-β-D-氨基葡萄糖苷酶）活性达50%。该药物在浓度为4×10⁻⁴ M时可抑制酸性脂肪酶55%，抑制酸性磷酸酶58%。
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