Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
Genomics. 2019 Jul;111(4):980-985. doi: 10.1016/j.ygeno.2018.06.005. Epub 2018 Jun 30.
Resistin, an adipokine, is involved in obesity and Type 2 Diabetes (T2D). The current study evaluates the association between RETN polymorphisms (-638 G/A, -420C/G & -358 G/A) and the risk towards T2D. Controls and T2D patients were enrolled from Gujarat, India. Polymorphisms of RETN were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. For the genotype-phenotype correlation analysis Fasting Blood Glucose (FBG), Body Mass Index (BMI) and plasma lipid profile were used. Plasma levels of resistin were assayed by ELISA. Our study suggests an association of RETN -420C/G polymorphism with T2D risk. The CC genotype of RETN -420C/G polymorphism was found to be associated with FBG, BMI, and total cholesterol. Plasma resistin levels were found to be significantly increased in diabetic patients as compared to controls. Our findings suggest -420C/G polymorphism of RETN as an important factor which could pose a powerful risk towards T2D susceptibility.
抵抗素是一种脂肪细胞因子，与肥胖和 2 型糖尿病（T2D）有关。本研究评估了 RETN 多态性（-638 G/A、-420C/G 和-358 G/A）与 T2D 风险之间的关系。对照组和 T2D 患者均来自印度古吉拉特邦。通过聚合酶链反应-限制性片段长度多态性检测 RETN 多态性。为了进行基因型-表型相关性分析，使用了空腹血糖（FBG）、体重指数（BMI）和血浆脂质谱。通过 ELISA 测定血浆抵抗素水平。我们的研究表明 RETN-420C/G 多态性与 T2D 风险相关。RETN-420C/G 多态性的 CC 基因型与 FBG、BMI 和总胆固醇有关。与对照组相比，糖尿病患者的血浆抵抗素水平显著升高。我们的研究结果表明，RETN-420C/G 多态性是一个重要的因素，可能对 T2D 的易感性构成强大的风险。
