Research Center for Emerging Viral Infections, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan 333, Taiwan, ROC.
Microbes Infect. 2011 May;13(5):479-88. doi: 10.1016/j.micinf.2011.01.013. Epub 2011 Jan 27.
The influenza viruses contain highly variable genomes and are able to infect a wide range of host species. Large-scale sequencing projects have collected abundant influenza sequence data for assessing influenza genome diversity and evolution. This work reviews current influenza sequence databases characteristics and statistics, as well as recent studies utilizing these databases to unravel influenza virus diversity and evolution. Also discussed are the newest deep sequencing methods and their applications to influenza virus research.
流感病毒的基因组高度可变，能够感染多种宿主物种。大规模测序项目已经收集了大量的流感序列数据，用于评估流感基因组的多样性和进化。这项工作回顾了当前流感序列数据库的特点和统计数据，以及最近利用这些数据库揭示流感病毒多样性和进化的研究。还讨论了最新的深度测序方法及其在流感病毒研究中的应用。
