Department of Genome Sciences, University of Washington, Seattle, WA, USA; Division of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Trends Microbiol. 2018 Sep;26(9):781-793. doi: 10.1016/j.tim.2018.02.007. Epub 2018 Mar 10.
The rapid global evolution of influenza virus begins with mutations that arise de novo in individual infections, but little is known about how evolution occurs within hosts. We review recent progress in understanding how and why influenza viruses evolve within human hosts. Advances in deep sequencing make it possible to measure within-host genetic diversity in both acute and chronic influenza infections. Factors like antigenic selection, antiviral treatment, tissue specificity, spatial structure, and multiplicity of infection may affect how influenza viruses evolve within human hosts. Studies of within-host evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape influenza virus's global evolution.
流感病毒在全球的迅速演变始于个体感染中新出现的突变，但人们对病毒在宿主体内如何进化知之甚少。我们综述了目前对流感病毒在人体宿主中如何以及为何进化的理解进展。深度测序技术的进步使得在急性和慢性流感感染中测量宿主内遗传多样性成为可能。抗原选择、抗病毒治疗、组织特异性、空间结构和感染复数等因素可能会影响流感病毒在人体宿主中的进化方式。对宿主内进化的研究有助于我们理解塑造流感病毒全球进化的进化和流行病学因素。
