• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio.

作者信息

Quistorff Bjørn, Grunnet Niels

出版信息

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):E21; author reply E22. doi: 10.1073/pnas.1017750108. Epub 2011 Jan 28.

DOI:10.1073/pnas.1017750108
PMID:21278331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3041136/
Abstract
摘要

相似文献

1
High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio.高脑乳酸并非由乳酸脱氢酶A/B比例的变化引起。
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):E21; author reply E22. doi: 10.1073/pnas.1017750108. Epub 2011 Jan 28.
2
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.大脑中乳酸水平升高是衰老的一个标志,是由乳酸脱氢酶 A/B 比值的变化引起的。
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. doi: 10.1073/pnas.1008189107. Epub 2010 Nov 1.
3
No evidence of an intracellular lactate shuttle in rat skeletal muscle.大鼠骨骼肌中不存在细胞内乳酸穿梭的证据。
J Physiol. 2002 Jun 1;541(Pt 2):569-74. doi: 10.1113/jphysiol.2002.016683.
4
Yak lactate dehydgogenase A4: purification, properties, and cDNA cloning.牦牛乳酸脱氢酶A4:纯化、性质及cDNA克隆
Biosci Biotechnol Biochem. 2008 Sep;72(9):2448-51. doi: 10.1271/bbb.80208. Epub 2008 Sep 7.
5
Age-related responses of right ventricle in swim-trained rats: changes in lactate and pyruvate contents and lactate dehydrogenase activity.游泳训练大鼠右心室的年龄相关反应:乳酸和丙酮酸含量及乳酸脱氢酶活性的变化
Mech Ageing Dev. 1996 Sep 18;90(2):91-102. doi: 10.1016/0047-6374(96)01749-6.
6
Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase.人源乳酸脱氢酶 M4 和 H4 同工型活性部位中丙酮酸和 L-乳酸结合的差异和相似性。
Arch Biochem Biophys. 2011 Jan 1;505(1):33-41. doi: 10.1016/j.abb.2010.10.010. Epub 2010 Oct 14.
7
In situ lactate dehydrogenase activity: a novel renal cortical imaging biomarker of tubular injury?原位乳酸脱氢酶活性:一种新型的肾小管损伤肾皮质成像生物标志物?
Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F465-F473. doi: 10.1152/ajprenal.00561.2015. Epub 2016 Sep 21.
8
Age related rise in lactate and its correlation with lactate dehydrogenase (LDH) status in post-mitochondrial fractions isolated from different regions of brain in mice.年龄相关的乳酸升高及其与从小鼠不同脑区分离的线粒体后部分离物中的乳酸脱氢酶 (LDH) 状态的相关性。
Neurochem Int. 2018 Sep;118:23-33. doi: 10.1016/j.neuint.2018.04.007. Epub 2018 Apr 18.
9
Lactic acid production with lactate dehydrogenase using the visible light sensitization of zinc porphyrin.利用锌卟啉的可见光敏化作用通过乳酸脱氢酶生产乳酸。
Photochem Photobiol Sci. 2004 Jul;3(7):681-3. doi: 10.1039/b309596g. Epub 2004 May 20.
10
Reduction of D-lactate content in sauerkraut using starter cultures of recombinant Leuconostoc mesenteroides expressing the ldhL gene.利用表达ldhL基因的重组肠膜明串珠菌发酵剂降低酸菜中D-乳酸含量。
J Biosci Bioeng. 2016 May;121(5):479-83. doi: 10.1016/j.jbiosc.2015.09.007. Epub 2015 Oct 21.

引用本文的文献

1
Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes.脑代谢在健康与神经退行性变中的作用:神经元与星形胶质细胞的相互作用。
Cells. 2024 Oct 17;13(20):1714. doi: 10.3390/cells13201714.
2
Brain energy metabolism: A roadmap for future research.脑能量代谢:未来研究的路线图。
J Neurochem. 2024 May;168(5):910-954. doi: 10.1111/jnc.16032. Epub 2024 Jan 6.
3
LncRNA GLTC targets LDHA for succinylation and enzymatic activity to promote progression and radioiodine resistance in papillary thyroid cancer.长链非编码 RNA GLTC 通过靶向 LDHA 促进琥珀酰化和酶活性,从而促进甲状腺乳头状癌的进展和抗放射性碘治疗。
Cell Death Differ. 2023 Jun;30(6):1517-1532. doi: 10.1038/s41418-023-01157-6. Epub 2023 Apr 8.
4
Lactate-Dependent Cross-Talk Between Astrocyte and GnRH-I Neurons in Hypothalamus of Aged Brain: Decreased GnRH-I Transcription.衰老大脑下丘脑星形胶质细胞与 GnRH-I 神经元之间的乳酸依赖性串扰: GnRH-I 转录减少。
Reprod Sci. 2022 Sep;29(9):2546-2564. doi: 10.1007/s43032-021-00814-w. Epub 2022 Feb 9.
5
Hyperpolarised C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.极化 C-MRI 可识别出中危人类前列腺癌中出现的糖酵解细胞群体。
Nat Commun. 2022 Jan 24;13(1):466. doi: 10.1038/s41467-022-28069-2.
6
Advances of Glycometabolism Engineering in Chinese Hamster Ovary Cells.中国仓鼠卵巢细胞糖代谢工程研究进展
Front Bioeng Biotechnol. 2021 Dec 2;9:774175. doi: 10.3389/fbioe.2021.774175. eCollection 2021.
7
Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons.突变导致人类诱导多能干细胞衍生神经元的代谢紊乱和生存受损。
Front Cell Neurosci. 2019 Jul 5;13:297. doi: 10.3389/fncel.2019.00297. eCollection 2019.
8
CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain.相互矛盾的观点:缺乏证据支持星形胶质细胞-神经元乳酸穿梭将神经元活动与大脑中的葡萄糖利用联系起来。
J Physiol. 2018 Feb 1;596(3):351-353. doi: 10.1113/JP274945. Epub 2018 Jan 2.
9
Is L-lactate a novel signaling molecule in the brain?L-乳酸是大脑中的一种新型信号分子吗?
J Cereb Blood Flow Metab. 2015 Jul;35(7):1069-75. doi: 10.1038/jcbfm.2015.77. Epub 2015 Apr 29.
10
Lactate is always the end product of glycolysis.乳酸总是糖酵解的终产物。
Front Neurosci. 2015 Feb 27;9:22. doi: 10.3389/fnins.2015.00022. eCollection 2015.

本文引用的文献

1
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.大脑中乳酸水平升高是衰老的一个标志,是由乳酸脱氢酶 A/B 比值的变化引起的。
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. doi: 10.1073/pnas.1008189107. Epub 2010 Nov 1.
2
Comments on point: counterpoint: the kinetics of oxygen uptake during muscular exercise do/do not manifest time-delayed phase. The kinetics of oxygen uptake during muscular exercise do manifest time-delayed phases.观点评论:正方观点与反方观点:肌肉运动期间摄氧量的动力学表现出/未表现出延迟阶段。肌肉运动期间摄氧量的动力学确实表现出延迟阶段。
J Appl Physiol (1985). 2009 Nov;107(5):1674-5. doi: 10.1152/japplphysiol.00897.2009.
3
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase.将表达数据纳入代谢模型:以乳酸脱氢酶为例的案例研究。
J Theor Biol. 2006 Jun 7;240(3):464-74. doi: 10.1016/j.jtbi.2005.10.007. Epub 2005 Dec 2.
4
Expression of lactate dehydrogenase A and B genes in different tissues of rats adapted to chronic hypobaric hypoxia.乳酸脱氢酶A和B基因在适应慢性低压缺氧大鼠不同组织中的表达
J Cell Biochem. 2003 May 1;89(1):67-79. doi: 10.1002/jcb.10484.