Polymer Chemistry and Technology, Group of Polymer Physics & BioMaterials, University Politehnica of Bucharest, 149 Calea Victoriei, Sector 1, 010072, Bucharest, Romania.
J Mater Sci Mater Med. 2011 Mar;22(3):451-60. doi: 10.1007/s10856-011-4233-7. Epub 2011 Jan 30.
Artificial bone composites exhibit distinctive features by comparison to natural tissues, due to a lack of self-organization and intimate interaction apatite-matrix. This explains the need of "bio-inspired materials", in which hydroxyapatite grows in contact with self-assembling natural polymers. The present work investigates the function of a rational design in the hydroxyapatite-forming potential of a common biopolymer. Gelatin modified through intrinsic interactions with calcium alginate led through freeze-drying to porous hydrogels, whose architecture, constitutive features and chemistry were investigated with respect to their role on biomineralization. The apatite-forming ability was enhanced by the porosity of the materials, while the presence of alginate-reinforced Gel elastic chains, definitely favored this phenomenon. Depending on the concentration, polysaccharide chains act as "ionic pumps" enhancing the biomineralization. The mineralization-promoting effect of the peptide-polysaccharide network strictly depends on the hydrogels structural, compositional and morphological features derived from the interaction between the above mentioned two components.
人工骨复合材料与天然组织相比具有独特的特性，这是由于缺乏自组织和紧密的磷灰石基质相互作用。这就解释了为什么需要“仿生材料”，在这种材料中，羟基磷灰石与自组装的天然聚合物接触生长。本工作研究了在常见生物聚合物的羟基磷灰石形成潜力中合理设计的作用。通过与藻酸钙的固有相互作用改性的明胶通过冷冻干燥形成多孔水凝胶，研究了其在生物矿化中的作用，考察了其结构、组成和化学性质。材料的多孔性增强了成磷能力，而藻酸盐增强的凝胶弹性链的存在，明显有利于这种现象。根据浓度的不同，多糖链作为“离子泵”增强了生物矿化。肽-多糖网络的促矿化作用严格取决于上述两种成分相互作用产生的水凝胶结构、组成和形态特征。
