Izumiyama N, Asami E, Itoh Y, Ohtsubo K
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan.
Acta Neuropathol. 1990;81(2):213-6. doi: 10.1007/BF00334510.
Alzheimer's neurofibrillary tangles (NFT) and paired helical filaments (PHF) were found in the pheochromocytoma cells of the adrenal gland removed from a 54-year-old female. By electron microscopy they were identical to those found in the brains affected by dementia of Alzheimer type. In the tumor cells, most of the PHF were found dispersed loosely in the cytoplasm, while typical NFT were infrequent. By immunoelectron microscopy using peroxidase-antiperoxidase method, both NFT and dispersed PHF were stained positively with a polyclonal antiserum to human tau protein. This is the first observation of NFT and PHF in paraneuronal tumor cells. The patient has no obvious Alzheimer's disease.
在一名54岁女性切除的肾上腺嗜铬细胞瘤细胞中发现了阿尔茨海默病神经原纤维缠结（NFT）和双螺旋丝（PHF）。通过电子显微镜观察，它们与在阿尔茨海默型痴呆患者大脑中发现的缠结和双螺旋丝相同。在肿瘤细胞中，大多数双螺旋丝松散地分散在细胞质中，而典型的神经原纤维缠结很少见。采用过氧化物酶-抗过氧化物酶法进行免疫电子显微镜观察，NFT和分散的双螺旋丝均被抗人tau蛋白多克隆抗血清阳性染色。这是副神经节瘤细胞中首次观察到NFT和PHF。该患者无明显的阿尔茨海默病。
