Berezina Tamara L, Khouri Albert S, Kolomeyer Anton M, Clancy Patrick S, Fechtner Robert D
Institute of Ophthalmology and Visual Science, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.
Eur J Ophthalmol. 2011 Jul-Aug;21(4):415-21. doi: 10.5301/EJO.2011.6299.
Various methods have been used for testing peripheral visual field disturbances such as defects caused by drug toxicity. Static threshold perimetry with Humphrey Field Analyzer (HFA) is widely available. The aim of this study was to better define the normal thresholds for peripheral visual field (PVF) sensitivity and to refine analysis strategies.
Automated PVF testing was performed with HFA 60-4 program in 33 normal subjects. Test locations were organized into inner, middle, and outer eccentricity rings and divided into 4 zones: nasal, temporal, superior, and inferior. The threshold visual sensitivity (TVS) in decibels was established for each point.
The majority of points with the lowest TVS and highest between-subject variability were located within the nasal area of the outer ring. Points with the highest TVS and least variability were detected in the inner ring and in the temporal area of the middle and outer rings. Mean zone TVS decreased and variability increased with increasing eccentricity.
The areas that demonstrate the highest between-subject consistency and thus might best reveal peripheral visual abnormalities with HFA 60-4 are the inner ring, inferior and temporal zone of the middle ring, and temporal zone of the outer ring. These observations may be useful for developing strategies to detect peripheral field loss at an early stage when central vision is not yet affected.
已采用多种方法来检测周边视野障碍，如药物毒性所致的缺陷。使用 Humphrey 视野分析仪（HFA）进行的静态阈值视野检查广泛可用。本研究的目的是更好地界定周边视野（PVF）敏感度的正常阈值，并完善分析策略。
对 33 名正常受试者使用 HFA 60 - 4 程序进行自动周边视野检测。测试位置被组织成内、中、外偏心环，并分为 4 个区域：鼻侧、颞侧、上方和下方。为每个点确定以分贝为单位的阈值视觉敏感度（TVS）。
TVS 最低且受试者间变异性最高的大多数点位于外环的鼻侧区域。TVS 最高且变异性最小的点在内环以及中环和外环的颞侧区域被检测到。平均区域 TVS 随着偏心度增加而降低，变异性增加。
在使用 HFA 60 - 4 时，受试者间一致性最高、因此可能最能揭示周边视觉异常的区域是内环、中环的下方和颞侧区域以及外环的颞侧区域。这些观察结果可能有助于制定在中心视力尚未受影响时早期检测周边视野缺损的策略。
