Rutkowski Paul, May Christian Albrecht
Ophthalmologist, 282 Harrison Ave. , Harrison, NY , USA.
Department of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universität Dresden , Dresden , Germany.
Front Neurol. 2016 Apr 7;7:49. doi: 10.3389/fneur.2016.00049. eCollection 2016.
To review the roles of the different vascular beds nourishing the inner retina [retinal ganglion cells (RGCs)] during normal development of the human eye, using our own tissue specimens to support our conclusions.
An extensive search of the appropriate literature included PubMed, Google scholar, and numerous available textbooks. In addition, choroidal and retinal NADPH-diaphorase stained whole mount preparations were investigated.
The first critical interaction between vascular bed and RGC formation occurs in the sixth to eighth month of gestation leading to a massive reduction of RGCs mainly in the peripheral retina. The first 3 years of age are characterized by an intense growth of the eyeball to near adult size. In the adult eye, the influence of the choroid on inner retinal nutrition was determined by examining the peripheral retinal watershed zones in more detail.
This delicately balanced situation of RGC nutrition is described in the different regions of the eye, and a new graphic presentation is introduced to combine morphological measurements and clinical visual field data.
利用我们自己的组织标本支持我们的结论，回顾在人眼正常发育过程中滋养视网膜内层[视网膜神经节细胞（RGCs）]的不同血管床的作用。
广泛检索适当的文献，包括PubMed、谷歌学术和众多现有教科书。此外，还研究了脉络膜和视网膜NADPH-黄递酶染色的整装标本。
血管床与RGC形成之间的首次关键相互作用发生在妊娠第六至第八个月，导致主要在外周视网膜的RGC大量减少。3岁之前的特点是眼球迅速生长至接近成人大小。在成年眼中，通过更详细地检查外周视网膜分水岭区来确定脉络膜对视网膜内层营养的影响。
描述了眼的不同区域中RGC营养这种微妙平衡的情况，并引入了一种新的图形呈现方式来结合形态学测量和临床视野数据。
