在甲病毒关节炎和肌炎小鼠模型中，依那西普导致疾病加重。
Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis.
作者信息
Zaid Ali, Rulli Nestor E, Rolph Michael S, Suhrbier Andreas, Mahalingam Suresh
机构信息
University of Canberra, Canberra, Australian Capital Territory, Australia.
出版信息
Arthritis Rheum. 2011 Feb;63(2):488-91. doi: 10.1002/art.30112.
OBJECTIVE
Mosquito-borne alphaviruses such as chikungunya virus, o'nyong-nyong virus, and Ross River virus (RRV) cause sporadic, sometimes large, outbreaks of rheumatic disease worldwide. This study was designed to test the effect of treating RRV-induced arthritis using the anti-tumor necrosis factor (anti-TNF) drug etanercept in a mouse model of rheumatic disease.
METHODS
Mice were infected with RRV and treated with etanercept. Weight gain was measured, tissue viral titers were determined, and histologic changes in muscle and joint tissues were assessed.
RESULTS
RRV-infected mice treated with etanercept showed decreased weight gain, higher viral titers in muscle, joints, and blood, and more tissue damage and inflammatory cell recruitment than RRV-infected mice without treatment.
CONCLUSION
Anti-TNF therapy is unlikely to be useful in treating alphaviral arthritides. During alphaviral epidemics, careful monitoring of patients being treated with anti-TNF agents may be warranted.
目的
诸如基孔肯雅病毒、奥尼永-尼永病毒和罗斯河病毒（RRV）等蚊媒甲病毒在全球范围内引发散发性、有时规模较大的风湿性疾病疫情。本研究旨在使用抗肿瘤坏死因子（抗TNF）药物依那西普在风湿性疾病小鼠模型中测试其治疗RRV诱导的关节炎的效果。
方法
将小鼠感染RRV并用依那西普进行治疗。测量体重增加情况，测定组织病毒滴度，并评估肌肉和关节组织的组织学变化。
结果
与未接受治疗的RRV感染小鼠相比，接受依那西普治疗的RRV感染小鼠体重增加减少，肌肉、关节和血液中的病毒滴度更高，组织损伤和炎症细胞募集更多。
结论
抗TNF疗法不太可能用于治疗甲病毒关节炎。在甲病毒流行期间，可能有必要对接受抗TNF药物治疗的患者进行密切监测。
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