Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Southport, Australia.
J Infect Dis. 2011 Oct 1;204(7):1026-30. doi: 10.1093/infdis/jir470.
Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infected mice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans.
基孔肯雅病毒（CHIKV）与人类传染性风湿疾病的爆发有关。使用 CHIKV 关节炎和肌炎的小鼠模型，我们表明，感染小鼠的组织中显著诱导了肿瘤坏死因子-α、干扰素-γ和单核细胞趋化蛋白 1（MCP-1）。在患有 CHIKV 引起的多关节痛和多关节炎的患者的血清中也检测到了相同的因子，其中 MCP-1 水平特别升高。Bindarit（MCP 抑制剂）治疗改善了小鼠的 CHIKV 疾病。对感染小鼠的肌肉和关节组织进行组织学分析表明，用 bindarit 治疗后炎症浸润减少。这些结果表明，bindarit 可能对治疗人类 CHIKV 引起的关节炎有用。
