Masfaraud J F, Monod G, Devaux A
Institut National de la Recherche Agronomique, Laboratoire d'Ecotoxicologie INRA-ENVL, Marcy l'Etoile, France.
Sci Total Environ. 1990 Nov;97-98:729-38. doi: 10.1016/0048-9697(90)90271-u.
7-Ethylresorufin O-deethylase (EROD) activity and the cytochrome P-450 content of liver and kidney microsomes were measured in male and female nase (Chondrostoma nasus) from the River Rhône (France) caught downstream and upstream of a PCB incineration plant. Concurrently, PCB concentrations in the flesh of nase were also measured. The results showed that sex affected hepatic, but not renal, EROD activity during gonadal maturation. The male nase demonstrated higher activity than the female. Upstream/downstream comparisons clearly revealed a more elevated hepatic EROD activity in fish contaminated by PCB pollution than in fish captured in the reference area throughout the reproductive cycle, demonstrating the reliability of this enzymatic activity as a biochemical indicator. Renal EROD activity did not seem to be sensitive to PCB pollution, since neither male nor female nase showed significant upstream/downstream differences.
在法国罗纳河捕获的雄性和雌性鼻鱼（Chondrostoma nasus）中，测量了肝脏和肾脏微粒体的7-乙基间苯二酚O-脱乙基酶（EROD）活性以及细胞色素P-450含量。这些鼻鱼分别来自一家多氯联苯焚烧厂下游和上游区域。同时，还测量了鼻鱼肉中的多氯联苯浓度。结果表明，在性腺成熟期间，性别对肝脏EROD活性有影响，但对肾脏没有影响。雄性鼻鱼的活性高于雌性。上游/下游比较清楚地显示，在整个生殖周期中，受多氯联苯污染的鱼类肝脏EROD活性比在参考区域捕获的鱼类更高，这表明这种酶活性作为生化指标的可靠性。肾脏EROD活性似乎对多氯联苯污染不敏感，因为雄性和雌性鼻鱼在上游/下游均未显示出显著差异。
