India Diabetes Research Foundation, Dr A. Ramachandran's Diabetes Hospitals, 28, Marshalls Road, Egmore, Chennai 600 008, Tamil Nadu, India.
Med Clin North Am. 2011 Mar;95(2):353-72, viii. doi: 10.1016/j.mcna.2010.11.006.
Primary prevention of type 2 diabetes is effective for curbing its epidemic. Lifestyle intervention has been found to be a highly effective, safe, and cost-effective method for the prevention of diabetes in high-risk persons, the benefit of which can extend for many years. Among the pharmacologic agents studied for prevention of diabetes, metformin has been found to be the safest. Interventions using drugs are less preferred because the drugs' effects tend to dissipate after their use is stopped and adverse effects may also result. The major challenge is to translate current knowledge into prevention programs at the national level.
预防 2 型糖尿病对于遏制其流行非常有效。生活方式干预已被发现是高危人群预防糖尿病的一种非常有效、安全且具有成本效益的方法，其益处可以持续多年。在研究用于预防糖尿病的药物中，二甲双胍被发现是最安全的。由于药物的作用在停止使用后往往会消失，而且还可能产生不良反应，因此较少使用药物干预。主要的挑战是将当前的知识转化为国家层面的预防计划。
