Hiroshima University Hospital, Department of Radiation Oncology, Hiroshima, Japan.
Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):660-9. doi: 10.1016/j.ijrobp.2010.10.004.
To evaluate the current status of stereotactic body radiotherapy (SBRT) and identify both advantages and disadvantages of its use in developing countries, a meeting composed of consultants of the International Atomic Energy Agency was held in Vienna in November 2006. Owing to continuous developments in the field, the meeting was extended by subsequent discussions and correspondence (2007-2010), which led to the summary presented here. The advantages and disadvantages of SBRT expected to be encountered in developing countries were identified. The definitions, typical treatment courses, and clinical results were presented. Thereafter, minimal methodology/technology requirements for SBRT were evaluated. Finally, characteristics of SBRT for developing countries were recommended. Patients for SBRT should be carefully selected, because single high-dose radiotherapy may cause serious complications in some serial organs at risk. Clinical experiences have been reported in some populations of lung cancer, lung oligometastases, liver cancer, pancreas cancer, and kidney cancer. Despite the disadvantages expected to be experienced in developing countries, SBRT using fewer fractions may be useful in selected patients with various extracranial cancers with favorable outcome and low toxicity.
为了评估立体定向体放射治疗（SBRT）的现状，并确定其在发展中国家应用的优缺点，国际原子能机构的顾问于 2006 年 11 月在维也纳举行了一次会议。由于该领域的不断发展，会议通过随后的讨论和通信（2007-2010 年）进行了延长，由此产生了此处的总结。确定了发展中国家预计会遇到的 SBRT 的优缺点。介绍了定义、典型治疗方案和临床结果。此后，评估了 SBRT 的最低方法/技术要求。最后，为发展中国家推荐了 SBRT 的特征。应该仔细选择 SBRT 患者，因为单次高剂量放疗可能会导致某些连续危险器官出现严重并发症。已经在肺癌、肺寡转移、肝癌、胰腺癌和肾癌的一些人群中报告了临床经验。尽管发展中国家预计会遇到缺点，但对于某些具有良好结局和低毒性的各种颅外癌症的患者，采用较少分割的 SBRT 可能会有用。
