Newsom-Davis Thomas, Bower Mark
Department of Oncology, Chelsea and Westminster Hospital NHS Foundation Trust 369 Fulham Road, London SW10 9NH UK.
F1000 Med Rep. 2010 Dec 8;2:85. doi: 10.3410/M2-85.
HIV-associated anal carcinoma, a non-AIDS-defining cancer, is a human papillomavirus-associated malignancy with a spectrum of preinvasive changes. The standardized incidence ratio for anal cancer in patients with HIV/AIDS is 20-50. Algorithms for anal cancer screening include anal cytology followed by high-resolution anoscopy for those with abnormal findings. Outpatient topical treatments for anal intraepithelial neoplasia include infrared coagulation therapy, trichloroacetic acid, and imiquimod. The development of cost-effective national screening programs for HIV-associated anal cancer remains a challenge.
与人类免疫缺陷病毒（HIV）相关的肛管癌是一种非艾滋病定义性癌症，是一种与人类乳头瘤病毒相关的恶性肿瘤，伴有一系列癌前病变。HIV/AIDS患者肛管癌的标准化发病率比为20至50。肛管癌筛查算法包括肛管细胞学检查，对于检查结果异常者随后进行高分辨率肛门镜检查。肛管上皮内瘤变的门诊局部治疗包括红外凝固疗法、三氯乙酸和咪喹莫特。制定具有成本效益的全国性HIV相关肛管癌筛查计划仍然是一项挑战。
