Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Org Biomol Chem. 2011 Mar 21;9(6):1927-37. doi: 10.1039/c0ob00813c. Epub 2011 Jan 31.
Here we describe general flow processes for the synthesis of alkyl and aryl azides, and the development of a new monolithic triphenylphosphine reagent, which provides a convenient format for the use of this versatile reagent in flow. The utility of these new tools was demonstrated by their application to a flow Staudinger aza-Wittig reaction sequence. Finally, a multistep aza-Wittig, reduction and purification flow process was designed, allowing access to amine products in an automated fashion.
在这里，我们描述了合成烷基和芳基叠氮化物的一般流程，并开发了一种新型整体式三苯基膦试剂，为该多功能试剂在流动相中使用提供了一种便捷的形式。这些新工具的应用通过其在流动态 Staudinger 氮杂-Wittig 反应序列中的应用得到了证明。最后，设计了一个多步氮杂-Wittig、还原和纯化的流动过程，以自动化的方式获得胺产物。
