Department of Otorhinolaryngology-Head and Neck Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Head Neck. 2012 Jan;34(1):120-6. doi: 10.1002/hed.21625. Epub 2011 Jan 31.
A key aspect for the postoperative prognosis of patients with head and neck cancer is complete tumor resection. In current practice, the intraoperative assessment of the tumor-free margin is dependent on visual appearance and palpation of the tumor. Optical imaging has the potential of traversing the gap between radiology and surgery by providing real-time visualization of the tumor, thereby allowing for image-guided surgery. The use of the near-infrared light spectrum offers 2 essential advantages: increased tissue penetration of light and an increased signal-to-background ratio of contrast agents. In this review, the current practice and limitations of image-guided surgery by optical imaging using intrinsic fluorescence or contrast agents are described. Furthermore, we provide an overview of the various molecular contrast agents targeting specific hallmarks of cancer that have been used in other fields of oncologic surgery, and we describe perspectives on its future use in head and neck cancer surgery.
对于头颈部癌症患者的术后预后，一个关键方面是完全切除肿瘤。在目前的实践中，肿瘤无边界的术中评估依赖于肿瘤的视觉外观和触诊。光学成像是有潜力的，可以通过实时可视化肿瘤来跨越放射学和外科之间的差距，从而实现图像引导手术。近红外光谱的使用提供了 2 个重要的优势：增加了光的组织穿透性和对比剂的信号与背景比增加。在这篇综述中，描述了使用固有荧光或对比剂的光学成像的图像引导手术的当前实践和局限性。此外，我们还概述了针对已在其他肿瘤外科领域中使用的癌症特定标志物的各种分子对比剂，并描述了其在头颈部癌症外科中的未来应用前景。
