Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Diabetes Technol Ther. 2011 Feb;13(2):149-55. doi: 10.1089/dia.2010.0101.
Liver fat content (LFC) in subjects without diabetes may be correlated with adverse glucose profiles.
LFC was measured by (1)H magnetic resonance spectroscopy in 47 healthy subjects, 35 of whom also completed continuous glucose monitoring (CGM) studies. Subjects were divided into two groups according to LFC, and between-group comparisons of glucose profiles were made.
The median LFC value was 3.8% (interquartile range, 2.4-7.6%), and 29.8% of the subjects had LFC values ≥ 5.5%. LFC was positively correlated with triglyceride, aspartate aminotransferase, γ-glutamyltransferase, fasting C-peptide, fasting insulin, insulin concentration at 120 min, area under the time-concentration curve for insulin, and change in insulin from 0 to 30 min, homeostatic model assessment of insulin resistance, fasting plasma glucose, nocturnal mean blood glucose concentration (MBG) (all P < 0.05). The 35 CGM profiles revealed that nocturnal MBG was higher in subjects with LFC ≥ 3.8% (P < 0.05). In subjects with LFC ≥ 5.5%, both diurnal and nocturnal MBG values were elevated compared with subjects with lower LFC (P < 0.05). LFC was the strongest predictive factor of nocturnal MBG.
Even modestly elevated LFC was associated with unfavorable glucose profiles in subjects without diabetes.
无糖尿病受试者的肝脂肪含量（LFC）可能与不良的血糖谱相关。
在 47 名健康受试者中通过（1）H 磁共振波谱法测量 LFC，其中 35 名受试者还完成了连续血糖监测（CGM）研究。根据 LFC 将受试者分为两组，并对两组间的血糖谱进行了比较。
LFC 的中位数为 3.8%（四分位距，2.4-7.6%），29.8%的受试者的 LFC 值≥5.5%。LFC 与甘油三酯、天冬氨酸转氨酶、γ-谷氨酰转移酶、空腹 C 肽、空腹胰岛素、120 分钟时的胰岛素浓度、胰岛素的时间-浓度曲线下面积和 0 至 30 分钟时胰岛素的变化、稳态模型评估的胰岛素抵抗、空腹血糖、夜间平均血糖浓度（MBG）呈正相关（均 P<0.05）。35 例 CGM 谱显示，LFC≥3.8%的受试者夜间 MBG 较高（P<0.05）。在 LFC≥5.5%的受试者中，日间和夜间 MBG 值均高于 LFC 较低的受试者（P<0.05）。LFC 是夜间 MBG 的最强预测因素。
即使是适度升高的 LFC 也与无糖尿病受试者的不良血糖谱相关。
