Auzzi G, Bruni F, Clauser M, Costanzo A, Pecori Vettori L, Ademollo B
Farmaco Sci. 1986 Sep;41(9):666-75.
The synthesis of some 2-[5-amino-1-methyl-3-oxo-4-pyrazolynyl]-1,3,4-thiadiazole derivatives is accomplished by reacting 5-amino-1-methyl-3-oxopryrazolynyl-4-dithiocarbohydrazide with carboxylic acid derivatives. The structure of the compounds obtained is verified by means of 1H and 13C-N.M.R. spectra. Antimicrobial and antifungal activity of some of the described compounds was tested in a preliminary screening.
通过使5-氨基-1-甲基-3-氧代吡唑啉基-4-二硫代氨基脲与羧酸衍生物反应来完成一些2-[5-氨基-1-甲基-3-氧代-4-吡唑啉基]-1,3,4-噻二唑衍生物的合成。所得到化合物的结构通过1H和13C核磁共振光谱进行验证。在初步筛选中测试了一些所述化合物的抗菌和抗真菌活性。