Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Finland.
Ann Med. 2011 Jun;43(4):312-9. doi: 10.3109/07853890.2010.549145. Epub 2011 Feb 1.
OBJECTIVE. We conducted the present study to examine the associations of two different paediatric metabolic syndrome (MetS) definitions and recovery from childhood MetS with arterial pulse wave velocity (PWV), an index of arterial stiffness, measured in adulthood. METHODS. A total of 945 subjects participated in the base-line study in 1986 (then aged 9-18 years) and the adult follow-up in 2007 (then aged 30-39 years). Cardiovascular risk factor data were available at both base-line and follow-up. In the follow-up study, arterial PWV was measured using a whole-body impedance cardiography device. RESULTS. Subjects suffering from MetS in childhood (prevalence 11.1%-14.1%) had higher arterial PWV after 21-year follow-up when compared with those not afflicted by the syndrome in childhood (P < 0.007). An increasing number of the MetS components in childhood were associated with increased PWV in adulthood (P for trend = 0.005). Subjects who recovered from the MetS during the 21-year follow-up period had lower PWV than those with persistent MetS (P < 0.001). CONCLUSION. MetS in childhood predicted increased arterial stiffness in adulthood, and recovery from childhood MetS was associated with decreased arterial PWV in adulthood. The current results emphasize the importance of the prevention and controlling of MetS risk factors both in childhood and adulthood.
目的。本研究旨在探讨两种不同的儿科代谢综合征（MetS）定义与儿童期 MetS 恢复与成人动脉脉搏波速度（PWV）的相关性，PWV 是动脉僵硬度的一个指标。
方法。共有 945 名受试者参加了 1986 年的基线研究（当时年龄为 9-18 岁）和 2007 年的成人随访研究（当时年龄为 30-39 岁）。基线和随访时均有心血管危险因素数据。在随访研究中，使用全身阻抗心动图仪测量动脉 PWV。
结果。与儿童期未患 MetS 的受试者相比（患病率为 11.1%-14.1%），儿童期患有 MetS 的受试者在 21 年随访后动脉 PWV 更高（P<0.007）。儿童期 MetS 成分数量的增加与成年期 PWV 的增加相关（趋势 P=0.005）。在 21 年随访期间从 MetS 中恢复的受试者的 PWV 低于持续患有 MetS 的受试者（P<0.001）。
结论。儿童期 MetS 预测成年期动脉僵硬度增加，儿童期 MetS 的恢复与成年期动脉 PWV 降低相关。目前的结果强调了在儿童期和成年期预防和控制 MetS 危险因素的重要性。
