Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Helsinki Clinic for Sports and Exercise Medicine, Foundation for Sports and Exercise Medicine, Helsinki, Finland.
Physiol Rep. 2024 May;12(9):e16024. doi: 10.14814/phy2.16024.
We investigated the associations of the measures of arterial health with cognition in adolescents and whether physical activity (PA) or sedentary time (ST) confounds these associations. One hundred sixteen adolescents (71 boys) aged 15.9 ± 0.4 participated in the study. PA and ST were assessed using a combined accelerometer/heart rate monitor. Overall cognition was computed from the results of psychomotor function, attention, working memory, and paired-associate learning tests. Pulse wave velocity was measured by impedance cardiography, carotid intima-media thickness, and carotid artery distensibility by carotid ultrasonography. Systolic and diastolic blood pressure (SBP and DBP) were measured using an aneroid sphygmomanometer. SBP was inversely associated with overall cognition (standardized regression coefficient [β] = -0.216, 95% confidence interval (CI) -0.406 to -0.027, p = 0.025). Pulse wave velocity (β = -0.199, 95% CI -0.382 to -0.017, p = 0.033) was inversely associated with working memory task accuracy. SBP was directly associated with reaction time in the attention (β = 0.256, 95% CI 0.069 to 0.443, p = 0.008) and errors in the paired-associate learning tasks (β = 0.308, 95% CI 0.126 to 0.489, p = 0.001). Blood pressure was inversely associated with overall cognition. PA or ST did not confound the associations. Results suggest that preventing high blood pressure is important for promoting cognition in adolescents.
我们研究了动脉健康指标与青少年认知之间的关系，以及身体活动（PA）或久坐时间（ST）是否会混淆这些关系。116 名青少年（71 名男孩）年龄为 15.9±0.4 岁参与了这项研究。PA 和 ST 使用组合加速度计/心率监测器进行评估。整体认知是从心理运动功能、注意力、工作记忆和配对联想学习测试的结果计算得出的。脉搏波速度通过阻抗心图测量，颈动脉内膜中层厚度和颈动脉可扩张性通过颈动脉超声测量。使用无液血压计测量收缩压和舒张压（SBP 和 DBP）。SBP 与整体认知呈负相关（标准化回归系数 [β] = -0.216，95%置信区间 [CI] -0.406 至 -0.027，p = 0.025）。脉搏波速度（β = -0.199，95%CI -0.382 至 -0.017，p = 0.033）与工作记忆任务准确性呈负相关。SBP 与注意力中的反应时间（β = 0.256，95%CI 0.069 至 0.443，p = 0.008）和配对联想学习任务中的错误（β = 0.308，95%CI 0.126 至 0.489，p = 0.001）呈正相关。血压与整体认知呈负相关。PA 或 ST 并未混淆这些关联。结果表明，预防高血压对于促进青少年的认知能力很重要。
