用自体骨髓细胞、血小板、纤维蛋白胶和胶原基质治疗难愈性伤口。
Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix.
机构信息
Vascular and Endovascular Research Center, Imamreza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Cytotherapy. 2011 Jul;13(6):705-11. doi: 10.3109/14653249.2011.553594. Epub 2011 Feb 2.
BACKGROUND AIMS
Recalcitrant diabetic wounds are not responsive to the most common treatments. Bone marrow-derived stem cell transplantation is used for the healing of chronic lower extremity wounds.
METHODS
We report on the treatment of eight patients with aggressive, refractory diabetic wounds. The marrow-derived cells were injected/applied topically into the wound along with platelets, fibrin glue and bone marrow-impregnated collagen matrix.
RESULTS
Four weeks after treatment, the wound was completely closed in three patients and significantly reduced in the remaining five patients.
CONCLUSIONS
Our study suggests that the combination of the components mentioned can be used safely in order to synergize the effect of chronic wound healing.
背景目的
难治性糖尿病伤口对最常见的治疗方法没有反应。骨髓源性干细胞移植用于治疗慢性下肢伤口。
方法
我们报告了 8 例侵袭性、难治性糖尿病伤口患者的治疗情况。将骨髓来源的细胞与血小板、纤维蛋白胶和骨髓浸渍胶原基质一起注射/局部应用于伤口。
结果
治疗 4 周后，3 例患者的伤口完全闭合，其余 5 例患者的伤口明显缩小。
结论
我们的研究表明，所述成分的组合可安全地用于协同慢性伤口愈合的效果。
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