Asadi Mehdi, Alamdari Daryoush Hamidi, Rahimi Hamid Reza, Aliakbarian Mohsen, Jangjoo Ali, Abdollahi Abbas, Bahar Mostafa Mehrabi, Azadmand Ali, Forghani Naser, Sadegh Mohammad Nori, Khayamy Mohammad Esmail, Seifalian Alexander
Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
Stem Cell and Regenerative Medicine Research Group, Department of Biochemistry, Stem Cell Laboratory, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
Exp Ther Med. 2014 Aug;8(2):423-429. doi: 10.3892/etm.2014.1747. Epub 2014 May 29.
Currently there is no ideal procedure for the treatment of recalcitrant ulcers that are unresponsive to the majority of common treatments. However, several novel approaches have been proposed, including bone marrow stem cells, platelets, fibrin glue and collagen matrix. For the first approach treatment of a chronic wound, a non-invasive method is highly desirable. The present study was undertaken with the aim of evaluating the effect of a combination of platelets, fibrin glue and collagen matrix (PFC) in one treatment. A total of ten patients with aggressive, refractory, life-threatening wounds were recruited for the study and their treatment effects were evaluated. Initially, the ulcers were extensively debrided, measured and photographed at weekly intervals. The PFC combination was applied topically to the wound every two days. Following treatment, the wound was completely closed in nine patients and was markedly reduced in the other patient. The mean 100% healing time for the nine patients was 11.3±5.22 weeks. There was no evidence of local or systemic complications or any abnormal tissue formation, keloid or hypertrophic scarring. Therefore, the results of the present study indicate that in the first approach, the combination of PFC components may be used safely in order to synergize the effect of chronic wound healing.
目前，对于大多数常规治疗均无反应的顽固性溃疡，尚无理想的治疗方法。然而，已经提出了几种新方法，包括骨髓干细胞、血小板、纤维蛋白胶和胶原基质。对于慢性伤口的首次治疗方法，非常需要一种非侵入性方法。本研究旨在评估血小板、纤维蛋白胶和胶原基质（PFC）联合使用在一次治疗中的效果。总共招募了10例患有侵袭性、难治性、危及生命伤口的患者进行研究，并评估了他们的治疗效果。最初，每周对溃疡进行广泛清创、测量和拍照。每两天将PFC组合局部应用于伤口。治疗后，9例患者的伤口完全愈合，另一例患者的伤口明显缩小。9例患者的平均100%愈合时间为11.3±5.22周。没有局部或全身并发症的证据，也没有任何异常组织形成、瘢痕疙瘩或肥厚性瘢痕的迹象。因此，本研究结果表明，在首次治疗中，PFC成分的组合可以安全使用，以协同慢性伤口愈合的效果。
