脂联素受体信号转导：当前模型的新层面。
Adiponectin receptor signaling: a new layer to the current model.
机构信息
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
Cell Metab. 2011 Feb 2;13(2):123-4. doi: 10.1016/j.cmet.2011.01.012.
PMID:21284979
Abstract
Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism partly via activation of AMP-activated protein kinase (AMPK). Recent work in Nature Medicine (Holland et al., 2011) suggests that adiponectin stimulates ceramidase activity through AdipoR1 and AdipoR2, an activity potentially involved in promoting cell survival.
摘要
脂联素及其受体，AdipoR1 和 AdipoR2，通过激活 AMP 激活的蛋白激酶 (AMPK) 部分调节葡萄糖和脂肪酸代谢。最近在《自然医学》（Holland 等人，2011）中的研究表明，脂联素通过 AdipoR1 和 AdipoR2 刺激神经酰胺酶活性，这种活性可能参与促进细胞存活。
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