脂联素引起了人们对钙的兴趣。
Adiponectin sparks an interest in calcium.
机构信息
Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia.
出版信息
Cell Metab. 2010 Jun 9;11(6):447-9. doi: 10.1016/j.cmet.2010.05.007.
PMID:20519115
Abstract
Adiponectin and its receptors, AdipoR1 and AdipoR2, regulate glucose and fatty acid metabolism via activation of AMP-activated protein kinase. Recent work in Nature (Iwabu et al., 2010) demonstrates that adiponectin induces a marked Ca(2+) influx in skeletal muscle via AdipoR1 to control mitochondrial biogenesis, reduce oxidative stress, and enhance endurance capacity.
摘要
脂联素及其受体 AdipoR1 和 AdipoR2 通过激活 AMP 激活的蛋白激酶来调节葡萄糖和脂肪酸代谢。《自然》杂志上的一项最新研究（Iwabu 等人，2010）表明，脂联素通过 AdipoR1 诱导骨骼肌中明显的 Ca(2+)内流，以控制线粒体生物发生、减少氧化应激并增强耐力。
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