Kim Sung-Hyun, Kang Sam-Suk, Jung Tae-Young, Jung Shin
Department of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, Korea.
J Korean Neurosurg Soc. 2010 Nov;48(5):445-7. doi: 10.3340/jkns.2010.48.5.445. Epub 2010 Nov 30.
Pilomyxoid astrocytoma (PMA) is a newly recognized variant of a pilocytic astrocytoma. This report describes a case of a pilomyxoid astrocytoma that occurred in the opticohypothalamus. The patient was a 18-year-old girl who complained decreased visual acuity and visual field over a period of two years. Magnetic resonance imaging (MRI) showed an irregular lobulated tumor with heterogeneous enhancement at the suprasellar region involving the hypothalamus. The mass was partially removed via the subfrontal approach. Its pathology was confirmed to be PMA. Adjuvant chemotherapy with cisplatin and vincristine was started following tumor resection. After four cycles, the mass showed a partial response to the chemotherapy. Although long-term outcome is yet to be determined, the administration of combined cisplatin and vincristine treatment seems to be an effective regimen for a pilomyxoid astrocytoma.
毛黏液样星形细胞瘤（PMA）是一种新认识的毛细胞型星形细胞瘤变体。本报告描述了一例发生于视交叉下丘脑区域的毛黏液样星形细胞瘤病例。患者为一名18岁女孩，她在两年时间里出现视力下降和视野缺损。磁共振成像（MRI）显示鞍上区域有一个不规则分叶状肿瘤，累及下丘脑，强化不均匀。通过额下入路部分切除了肿块。其病理确诊为PMA。肿瘤切除后开始使用顺铂和长春新碱进行辅助化疗。四个周期后，肿块对化疗有部分反应。尽管长期预后尚待确定，但顺铂和长春新碱联合治疗似乎是毛黏液样星形细胞瘤的一种有效治疗方案。
