Chemical and Environmental Engineering Department, University of California, Riverside, CA 92521, USA.
Chem Commun (Camb). 2011 Apr 7;47(13):3793-5. doi: 10.1039/c0cc04733c. Epub 2011 Feb 2.
Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP.
在这里，我们报告了基于单壁碳纳米管（SWNTs）的化学电阻适体传感器，用于使用置换格式对弱电荷或非电荷分子进行高灵敏度和选择性检测。作为概念验证，我们展示了通过置换与小捕获寡核苷酸共价连接的 ssDNA 抗-ATP 适体来检测 ATP（一种小的弱电荷分子），其对 GTP 具有皮摩尔级的灵敏度和选择性。
