Department of Chemical and Materials Engineering, National Central University, Jhongli 320, Taiwan.
Molecules. 2020 Feb 5;25(3):680. doi: 10.3390/molecules25030680.
Aptamers, in sensing technology, are famous for their role as receptors in versatile applications due to their high specificity and selectivity to a wide range of targets including proteins, small molecules, oligonucleotides, metal ions, viruses, and cells. The outburst of field-effect transistors provides a label-free detection and ultra-sensitive technique with significantly improved results in terms of detection of substances. However, their combination in this field is challenged by several factors. Recent advances in the discovery of aptamers and studies of Field-Effect Transistor (FET) aptasensors overcome these limitations and potentially expand the dominance of aptamers in the biosensor market.
适体在传感技术中因其作为各种应用中的受体而闻名，因为它们对广泛的目标（包括蛋白质、小分子、寡核苷酸、金属离子、病毒和细胞）具有高特异性和选择性。场效应晶体管的爆发为无标记检测和超灵敏技术提供了可能，这在物质检测方面取得了显著改善的结果。然而，它们在这一领域的结合受到了几个因素的挑战。最近在适体发现和场效应晶体管（FET）适体传感器研究方面的进展克服了这些限制，并有可能扩大适体在生物传感器市场的优势。
